CALCIUM HOMEOSTASIS IN CHILDREN WITH ß-THALASSEMIA MAJOR | ||
| Al-Azhar Journal of Pediatrics | ||
| Article 13, Volume 18, Issue 2, June 2015, Pages 1418-1433 PDF (244.4 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/azjp.2015.101757 | ||
| Authors | ||
| Mosallam Mohamed El-Sayed Nasser; Nadia Maher Nour; Ali Abdel Latief Afia; Nagwa Abd El-Aziz Kandoch; Ali Abd El-Aziz Ali; Mohammed Gamal Abu EL-Gait | ||
| Abstract | ||
| Objective: The aim of this meta analysis study is the change in calcium, phosphorus , 25-OH vitamin D3 , alkaline phosphatase and parathyroid hormone level among children with B-thalassemia major. Subject and Methods: The study group consisted of forty β-thalassemia patients , their ages ranged from 12-18 years and control group of forty healthy children. Inclusion criteria patients were diagnosed as β-thalassemia major depending on regular blood transfusions and blood samples were withdraw just pretansfusions. The results of serum total calcium , Ionized calcium , phosphorus ,alkaline phosphatase and serum parathyroid hormone were evaluated in both group. Results: the mean serum total calcium (8.9 ± 1.3 mg/dl) was non significantly lower among β-thalassemia patients than control (9.1± 0.7 mg/dl). Phosphorus (6.6 ± 2mg/dl) and serum 25-OH vitamin D3 (12.9 ± 4.5 ng/ml) were significantly lower among β-thalassemia patients than control (23.8± 10.5 ng/ml) .Serum parathyroid hormone (26.8 ± 6.5 pg/ml) was significantly lower among β-thalassemia patients than control (31.9± 5.2 pg/ml). Conclusion: there were significant negative correlation between serum parathyroid hormone and both alkaline phosphatase and ferritin and a significant positive correlation between serum parathyroid hormone and 25-OH vitamin D3 | ||
| Keywords | ||
| : B-thalassemia; calcium; phosphorus; 25-OH vitamin D3; alkaline phosphatase and parathyroid hormone | ||
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