FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE
Kassem, M., Nouh, A., El-Bayomy, T., Kassem, A. (1983). FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE. EKB Journal Management System, 6(2), 387-398. doi: 10.21608/bfsa.1983.102097
M. A. A. Kassem; A. T. Nouh; T. El-Bayomy; Alaa A. A. Kassem. "FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE". EKB Journal Management System, 6, 2, 1983, 387-398. doi: 10.21608/bfsa.1983.102097
Kassem, M., Nouh, A., El-Bayomy, T., Kassem, A. (1983). 'FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE', EKB Journal Management System, 6(2), pp. 387-398. doi: 10.21608/bfsa.1983.102097
Kassem, M., Nouh, A., El-Bayomy, T., Kassem, A. FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE. EKB Journal Management System, 1983; 6(2): 387-398. doi: 10.21608/bfsa.1983.102097

FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE

Bulletin of Pharmaceutical Sciences Assiut University
Article 11, Volume 6, Issue 2, December 1983, Page 387-398  XML PDF (336.37 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1983.102097
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Authors
M. A. A. Kassem1; A. T. Nouh2; T. El-Bayomy3; Alaa A. A. Kassem4
1Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
2Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
3National Organization for Drug and Research, Giza, Egypt
4Department of Pharmaceutics, Faculty of Pharmacy, El-Azhr University, Nasr City, Cairo, Egypt
Abstract
Spray granulation technique using fluidized bed was used for preparing riboflavin granules. Five binders were used for granulation as spray liquids, Polyvinylpyrrolidone proved to be the most suitable binder followed by sodium alginate and sodium carboxy methyl cellulose. Methyl cellulose produced tablets which disintegrated within the U.S.P.XX. Limit, but of low dissolution rate; while ethyl cellulose gave tablets which did not conform to the official Limit, but the drug was released from the tablet matrix faster than from tablets prepared by methyl cellulose.
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