The Efficacy of Squamous Cell Carcinoma Antigen in the Differential Diagnosis of Oral squamous Cell Carcinoma. | ||
| Egyptian Dental Journal | ||
| Article 11, Volume 66, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2020, Pages 1611-1617 PDF (617.31 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2020.33181.1150 | ||
| Authors | ||
| Maha Abdelkawy* 1; Shereen Ali2; Ahmed Nabil Fahmi3; Olfat Shaker4 | ||
| 1Lecturer of Oral Diagnosis, Oral Medicine, and Periodontology, Beni-Suef university, Egypt. | ||
| 2Oral Medicine and Periodontology Faculty of Oral and Dental Medicine Cairo University | ||
| 3Department of Oral Pathology, Faculty of Dentistry Beni-Suef university, Egypt | ||
| 4Department of Biochemistry, Faculty of Medicine, Cairo University | ||
| Abstract | ||
| Abstract Background and Objectives: Oral squamous cell carcinoma (OSCC) is a major oral cancer representative. Squamous cell carcinoma antigen (Scc-AG) is detected in squamous cell carcinoma of oral tissues and other different tissues. Oral lichen planus (OLP) is a chronic inflammatory disease with questionable malignant transformation. Methods: Forty-five participants divided into OSCC group and two control groups: oral lichen planus as an inflammatory disease (positive control) and healthy volunteers (negative control). Clinical staging and grading of OSCC was recorded. A double-antibody sandwich enzyme-linked immunosorbent assay was used to evaluate the level of Scc-AG in serum and saliva. Results: Statistically significant difference for serum and salivary Scc-Ag, was found between the groups; OSCC, OLP on one hand and healthy controls on the other hand. No statistically significant difference was found between OSCC and OLP control groups in serum levels, while for salivary Scc-Ag a statistically significant difference was found between these two groups, with the higher values in OLP. Staging and grading in OSCC group were not found to be related to Scc-Ag level. Conclusion: Serum Scc-Ag cannot be used as a biomarker to differentiate between oral malignant and chronic inflammatory lesions. On the other hand, salivary Scc-Ag determination provides results more reliable than serum Scc-Ag and could be used in monitoring inflammatory oral disease activity as well as malignant conditions and could differentiate between them. | ||
| Keywords | ||
| Squamous Cell Carcinoma Antigen; Biomarker; Oral squamous cell carcinoma; Oral lichen Planus; Salivary biomarkers | ||
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