EFFECT OF NITRIC OXIDE IN CHRONIC EXPERIMENTAL TOXOPLASMA GONDII INFECTION: HISTOPATHOLOGICAL AND HISTOCHEMICAL STUDY | ||
| Zagazig University Medical Journal | ||
| Article 511, Volume 27, Issue 5, September 2021, Pages 938-947 PDF (1.2 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2020.29297.1839 | ||
| Authors | ||
| Marwa Omar1; Beessa Abaza El-Sayed Abaza2; Esraa Mousa2; Hayam Elsaid Rashed3; Tahani Ismail Farag* 2 | ||
| 1Medical parasitology ,faculty of medicine , Zagazig university ,Zagazig ,Egypt | ||
| 2Medical parasitology ,faculty of medicine ,Zagazig university ,Zagazig ,Egypt | ||
| 3department of pathology, zagazig university egypt | ||
| Abstract | ||
| Aim of the work: To evaluate the histopathological alterations and immuno-histochemical pattern in chronic Toxoplasma gondii infection, and to evaluate the role aminoguanidine in experimental toxoplasmosis. Subjects and methods: This study was carried out on 48 laboratory-bred male Swiss albino mice which were divided into 4 groups (non-infected control; infected control; infected and treated with spiramycin; infected and treated with aminoguanidine). The effect of the used drugs was assessed using parasitological, histopathological and immunohistochemical approaches. Results: There was highly significant (P | ||
| Keywords | ||
| Toxoplasmosis; Aminoguanidine; Immunohistochemical; Spiramycin; iNOS | ||
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