ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES | ||
Bulletin of Pharmaceutical Sciences Assiut University | ||
Article 10, Volume 1, Issue 1, 1978, Pages 151-161 PDF (436.18 K) | ||
Document Type: Original Article | ||
DOI: 10.21608/bfsa.1978.104913 | ||
Authors | ||
A. A. El-Koussi1; A. M. Abdel-Aleem2; A. M. Afifi1 | ||
1Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
Abstract | ||
The present study was aimed at evaluating the anti-inflammatory action and toxicity of seven N-[-l-(p-nitrophenyl)-l,3-dihydroxy isopropyl]-N'-(substituted) oxamides (1). The compounds are designed to include the following moieties: anthranilic and p-aminosalicylic acids and p-aminophenol in their basic structures. Two dose levels of these compounds were assessed for their anti--inflammatory property in rate by the trypan blue method and using acetyl salicylic acid as the reference anti-inflammatory agent. Median lethal doses of the compounds were determined in mice. The possible correlation between structure and biological activity is suggested. | ||
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