Role of Monocyte Chemoattractant Protein-1 for Diagnosing Acute Myocardial Infarction
Omran, M., Zahran, F., Kadry, M., Belal, A., S, R. (2019). Role of Monocyte Chemoattractant Protein-1 for Diagnosing Acute Myocardial Infarction. EKB Journal Management System, 5(1), 8-17. doi: 10.21608/jbaar.2019.105887
Mohamed M. Omran; Faten M. Zahran; Mohamed Kadry; Arafa A. M. Belal; Reihan M S. "Role of Monocyte Chemoattractant Protein-1 for Diagnosing Acute Myocardial Infarction". EKB Journal Management System, 5, 1, 2019, 8-17. doi: 10.21608/jbaar.2019.105887
Omran, M., Zahran, F., Kadry, M., Belal, A., S, R. (2019). 'Role of Monocyte Chemoattractant Protein-1 for Diagnosing Acute Myocardial Infarction', EKB Journal Management System, 5(1), pp. 8-17. doi: 10.21608/jbaar.2019.105887
Omran, M., Zahran, F., Kadry, M., Belal, A., S, R. Role of Monocyte Chemoattractant Protein-1 for Diagnosing Acute Myocardial Infarction. EKB Journal Management System, 2019; 5(1): 8-17. doi: 10.21608/jbaar.2019.105887

Role of Monocyte Chemoattractant Protein-1 for Diagnosing Acute Myocardial Infarction

Journal of Bioscience and Applied Research
Article 2, Volume 5, Issue 1, March 2019, Pages 8-17    PDF (439.54 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2019.105887
Authors
Mohamed M. Omran* 1; Faten M. Zahran2; Mohamed Kadry3; Arafa A. M. Belal3; Reihan M S4
1Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt
2Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
3Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt
4Cardiology Department, Faculty of Medicine, New Damietta, Al-Azhar University, Egypt
Abstract
Background: Acute myocardial infarction (AMI) controlled and promoted by inflammation within the coronary plaque. Monocyte chemoattractant protein-1 (MCP-1) is a pro-inflammatory mediator, that’s playing a major role in plaque rupture. This study aimed to assess the diagnostic performance of MCP-1 for early diagnosis of AMI among chest pain (CP) patients. Methods: MCP-1 and cardiac Troponin I (cTnI) were performed for all studied patients. The receiver operating characteristic (ROC) curve was used to assess the diagnostic accuracy of biomarkers. Results: The baseline level of MCP-1 has a good capacity for discriminating patients with AMI from non-coronary chest pain (NCCP), stable angina (SA), and unstable angina (UA) patients with efficiency 91%, 91%, and 83%; respectively. Area under the curves (AUCs) of MCP-1 for diagnosis AMI patients at 0-6 hours and > 6-12 hours after onset time of CP were 0.69 (P < 0.001); and 0.71(P < 0.0001); respectively, compared with cTnI were 0.58 (P < 0.001) and 0.67 (P < 0.001); respectively. However, at > 12-24 hours, cTnI has AUC 0.93 (P < 0.0001) compared with MCP-1 0.74 (P < 0.0001). In conclusion: Independent early baseline MCP-1 has given sufficient diagnostic information for patients with AMI.
Keywords
Acute Myocardial Infarction; Biomarkers; Monocyte Chemoattractant Protein-1; Chest pain
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