Assessment the Serum progranulin level as a biomarker for retinopathy in type 2 diabetic patients | ||||
| Zagazig University Medical Journal | ||||
| Article 15, Volume 29, Issue 1.1, January 2023, Page 99-105 PDF (308.14 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2020.33166.1881 | ||||
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| Authors | ||||
Ismaeil Abdalla Habibi  1; Yasser Samir Sheta2; Nermin Raafat Abdelfattahh3; Islam Maher Wahid4
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| 1M.B.B.Ch., Department of Internal Medicine, Faculty of Medicine, Tripoli University, Libya | ||||
| 2Professor of Internal Medicine, Faculty of Medicine, Zagazig University | ||||
| 3Assistant professor of Medical Biochemistry, Faculty of Medicine, Zagazig University | ||||
| 4Lecturer of Internal Medicine, Faculty of Medicine Zagazig University | ||||
| Abstract | ||||
| Background: Micro vascular complications of T2DM are associated with severe morbidity, mortality and a huge economic burden. So, there is an important need to identify new biomarker able to identify disease onset and progression and can be used as a therapeutic target for management of these complications. The Aim of this study was to assessment the Serum progranulin level as a biomarker for the presence and severity of retinopathy in type 2 diabetic patients. Patients and Methods: The current case-control study was carried out conducted on (48 type 2 diabetic patients) at the Internal Medicine and ophthalmology out-patient clinic of Zagazig University Hospitals, during the period from May 2019 to October 2019. All patient referred to ophthalmic out-patient clinic for fundal examination by ophthalmologist ,in which diabetic retinopathy was diagnosed, a complete physical examination including the measurement of height, weight, body mass index, and blood pressure (BP) was performed for all patients. Results: The current study showed that there was a high statistical significant increase in serum PGRN level in diabetic patients with retinopathy, there was a statistical significant positive correlation between serum PGRN level with disease duration, urea, creatinine level and urinary ACR of studied retinopathy patients and also there was a high statistical significant increase in serum PGRN level in diabetic patients with proliferative retinopathy. Conclusions: According to our results serum PRGN level could be used as a biomarker for the presence of microvascular retinal complication and to anticipate the severity of diabetic retinopathy in T2DM patients | ||||
| Keywords | ||||
| Progranulin; Retinopathy; Nephropathy; Type 2 Diabetic | ||||
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