Systemic Review: Role of Tissue Plasminogen Activator for Acute Ischemic Stroke | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 8, Volume 70, Issue 7, January 2018, Pages 1121-1130 PDF (1018.6 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0044536 | ||
| Authors | ||
| Abdullah Musari Alanazi; Abdullah Munif Al-Enezi; Khalid Hashim Alanazi; Muteb Lafi Alanazi; Nasser Nidaa Alanazi | ||
| Northern Border University | ||
| Abstract | ||
| Background: Using recombinant tissue plasminogen activator (rt-PA) during the first 3 h up to 6 h of stroke was allowed to reduce the poor functional consequences of stroke. Objectives: assess the effects of intravenous dosage of rt-PA during the first 6 h after on early and late outcomes of acute ischemic stroke (AIS). Methods: all studies regarding the intravenous rt-PA given within 6 h of onset of acute ischemic stroke up to 2016 were searched the outcomes, and the mortality rates were evaluated at the final follow up. Results: There was a significant increase in functional outcome by using IV-tPA significantly (p <0.01). A significant decrease was found in intracranial hemorrhage in the patients treated with IV-tPA. The mortality rates were significantly decreased at the end of the follow up period in patients treated with IV-tPA. Conclusion: The study indicated that using intravenous rt-PA could increase the number of living patients favorable outcome, less disabilities and intracranial hemorrhage among acute ischemic stroke patients during the first 6 hours. | ||
| Keywords | ||
| Systemic review; tissue plasminogen activator; acute ischaemic stroke; mortality | ||
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