Role of Proton-Magnetic Resonance Spectroscopy (H1-MRS) in Evaluation of Spinal Cord in Multiple Sclerosis Patients. | ||||
| Zagazig University Medical Journal | ||||
| Article 41, Volume 29, Issue 1.1, January 2023, Page 299-306 PDF (536.37 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2020.25006.1755 | ||||
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| Authors | ||||
Sara Kamel El Demerdash  1; Ahmed Sabry Ragheb2; Faten Mohamed Hafez2; Mohamed Ashraf Zaitoun2
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| 1radiology department-faculty of medicine-zagazig university | ||||
| 2Radiology department, faculty of medicine, Zagazig university. | ||||
| Abstract | ||||
| Abstract: BACKGROUND: Proton MR spectroscopy (H1-MRS) is currently considered a useful technique for evaluating axonal damage and demyelination in MS, however, only few spectroscopic cervical MS study have been published because of the technical difficulties. PATIENTS AND METHODS: twenty patients with multiple sclerosis were encountered in the study and subjected to clinical assessment including full history taking, clinical examination and imaging assessment by cMRI and functional MRI. We determined the metabolic profile of each case as regard to control group. RESULTS: comparison of the main metabolites ratios between different studied groups (MS cord plaque group and control group), Cho/Cr, NAA/Cr, mI/Cr& NAA/Cho of control, acute MS, relapsing MS and progressive MS groups were 0.52±0.1, 0.62±0.08, 0.55±0.06, 0.59±0.02, 1.1±0.15, 1.3±0.02, 1.4±0.1, 0.9±0.03, 1.4±0.13, 2.3±0.2, 1.6±0.3, 2.08±0.04, 3.9±0.9, 2.0±0.04, 1.4±0.08 and 1.2±0.06 respectively with P value | ||||
| Keywords | ||||
| KEYWORDS: Spinal cord; Multiple sclerosis; Proton MR spectroscopy (H1 MRS) | ||||
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