Sulfonamides: Synthesis and the recent applications in Medicinal Chemistry
El-Gaby, M., A. Ammar, Y., I. H. El-Qaliei, M., M. ali, A., F. Hussein, M., A. Faraghally, F. (2020). Sulfonamides: Synthesis and the recent applications in Medicinal Chemistry. EKB Journal Management System, 63(12), 5289-5327. doi: 10.21608/ejchem.2020.33860.2707
Mohamed El-Gaby; Yousry A. Ammar; Mohamed I. H. El-Qaliei; Ahmed M. ali; Modather F. Hussein; Faraghally A. Faraghally. "Sulfonamides: Synthesis and the recent applications in Medicinal Chemistry". EKB Journal Management System, 63, 12, 2020, 5289-5327. doi: 10.21608/ejchem.2020.33860.2707
El-Gaby, M., A. Ammar, Y., I. H. El-Qaliei, M., M. ali, A., F. Hussein, M., A. Faraghally, F. (2020). 'Sulfonamides: Synthesis and the recent applications in Medicinal Chemistry', EKB Journal Management System, 63(12), pp. 5289-5327. doi: 10.21608/ejchem.2020.33860.2707
El-Gaby, M., A. Ammar, Y., I. H. El-Qaliei, M., M. ali, A., F. Hussein, M., A. Faraghally, F. Sulfonamides: Synthesis and the recent applications in Medicinal Chemistry. EKB Journal Management System, 2020; 63(12): 5289-5327. doi: 10.21608/ejchem.2020.33860.2707

Sulfonamides: Synthesis and the recent applications in Medicinal Chemistry

Egyptian Journal of Chemistry
Article 50, Volume 63, Issue 12, December 2020, Pages 5289-5327    PDF (4.14 M)
Document Type: Review Articles
DOI: 10.21608/ejchem.2020.33860.2707
Authors
Mohamed El-Gaby1; Yousry A. Ammar2; Mohamed I. H. El-Qaliei* 3; Ahmed M. ali4; Modather F. Hussein5; Faraghally A. Faraghally6
1Department of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, Egypt
2Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo
3Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut
4Department of Chemistry, Faculty of Science, Al-Azhar University, assiut
5Department of Chemistry, Faculty of Science, Al-Azhar University , Assiut
6Department of Chemistry, Faculty of Science, Al-Azhar University , Assiut.
Abstract
This review spotlights sulfonamides from different sides, including history, structure-activity relationship, chemistry, methods of classification and up to date ways for their synthesis. Moreover, the review includes a discussion of the varied pharmacological effects of sulfonamides. Sulfonamides have a good range of pharmacological activities like oral diuretics (furosemide, indapamide, chlorthalidone, thiazides); anticancer (E7070), carbonic anhydrase (CA) inhibitors (CAIs) (acetazolamide, dichlorophenamide, dorzolamide and brinzolamide), antiepileptics (zonisamide and sulthiame), for rheumatoid arthritis (Sulfasalazine) antiviral (Darunavir) anti-inflammatory (celecoxib), antibacterial (Sulfadizine), as Ophthamologicals (Dorzolamide) anticonvulsant (Zonisamide) cycloxygenase 2 (COX2) inhibitors (valdecoxib). these days, novel pills are launched, like apricoxib and pazopanib, which additionally include this organization. The sulfonamides competitively inhibit vitamin Bc synthesis in micro-organisms and subsequently inhibit multiplication of bacteria but don't actively kill them. they need been used against most gram-positive and lots of gram-negative bacteria, also as some fungi.
Keywords
sulfonamides. Medicinal Chemistry. Pharmacological activities. Micro; organisms
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