STUDY ON THIAZOLOPYRIDINES PART (7) : SYNTHESIS OF NOVEL THIAZOLIDINONE AND THIAZOLO[3,2-A]PYRIDINE DERIVATIVES

ELHAG ALI, GAMEEL A.; ALTAMAMY, HESSEN A.; MOHAMED, SHAABAN I.; BASHER, ZAMZAM A.

doi:10.21608/absb.2008.10835

	STUDY ON THIAZOLOPYRIDINES PART (7) : SYNTHESIS OF NOVEL THIAZOLIDINONE AND THIAZOLO[3,2-A]PYRIDINE DERIVATIVES
Al-Azhar Bulletin of Science
Article 14, Volume 2008, Issue 12, December 2008, Page 193-199 PDF (326.53 K)
Document Type: Original Article
DOI: 10.21608/absb.2008.10835
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Authors
GAMEEL A. ELHAG ALI^* ¹; HESSEN A. ALTAMAMY²; SHAABAN I. MOHAMED³; ZAMZAM A. BASHER²
¹Department of Chemistry, Faculty of science, Al-Azhar University, Cairo, Egypt
²Department of Chemistry, Faculty of science, Sebha University, Sebha, Libya
³Technology Engineering Institute, Tamooh , Giza
Abstract
A novel 2-ethoxycarbonyl methylidine-4,5-dihydo-4-oxo-5-arylmethylidine-1,3-thiazole derivatives (2a-c) are obtained via the reaction of 4-thiazolinone derivative (1) with different aromatic aldehydes. Cyclization of 4-thiazolidinone derivatives (2a-c) with various α–cyanocinnamonitriles afforded the corresponding thiazolopyridine derivatives (5a-r). Thiazolopyridine derivatives (5a,b ) are refluxed with acetic anhydride, and gave N,N-diacetyl amino derivatives (8a,b).
Keywords
THIAZOLOPYRIDINES; pyridine derivatives


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