NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE
ABU-SHANAB, F. (2007). NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE. EKB Journal Management System, 2007(6), 151-161. doi: 10.21608/absb.2007.10871
FATHI A. ABU-SHANAB. "NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE". EKB Journal Management System, 2007, 6, 2007, 151-161. doi: 10.21608/absb.2007.10871
ABU-SHANAB, F. (2007). 'NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE', EKB Journal Management System, 2007(6), pp. 151-161. doi: 10.21608/absb.2007.10871
ABU-SHANAB, F. NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE. EKB Journal Management System, 2007; 2007(6): 151-161. doi: 10.21608/absb.2007.10871

NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE

Al-Azhar Bulletin of Science
Article 2, Volume 2007, Issue 6, June 2007, Page 151-161  XML PDF (311.73 K)
Document Type: Original Article
DOI: 10.21608/absb.2007.10871
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Author
FATHI A. ABU-SHANAB*
Chemistry Department, Faculty of Science, Al-Azhar University, Assiut 71524,
Abstract
Treatment of N-aryl 2-chloroacetamides (2a-f) with sodium isopropoxide in isopropyl alcohol afforded 1,4-diarylppiperazine-2,5-dione (3a-f). Treatment of malononitrile dimer (9), ethyl cyanoacetate (11) and the arylidines of cyanothioacetamide (13) with DMFDMA afforded the corresponding enamines (10, 12 and 14) respectively. Reaction of 14 with either sodium ethoxide or sodium methoxide affords 5-cyano-4-ethoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (15) and  5-cyano-4-methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (16) respectively.
Keywords
1, 4-DIARYLPIPERAZINE-2, 5-DIONE; 3, 4, 5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE
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