SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY | ||
| Al-Azhar Bulletin of Science | ||
| Article 15, Volume 2007, Issue 6, June 2007, Pages 103-114 PDF (379.59 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/absb.2007.11106 | ||
| Author | ||
| S. A. HESSEIN* | ||
| Chemistry Department, Faculty of Science (Girl’s), Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Treatment of 1-[6-hydroxy-4-methoxybenzofuran-5-yl]ethanone (1) with cinnamaldehyde gave 1-[6-hydroxy-4-methoxybenzofuran-5-yl]-5-phenylpenta-2,4-diene-1-one (2) which reacted with formaline and 4-chloroniline to give benzofuran derivative (3) according to Mannich reaction. Interaction of 2 with 20% of sulphuric acid, malononitrile, ethylcyano acetate, phenyl hydrazine and guanidine hydrochloride afforded the corresponding furo[3,2-g]chromon-5-one (4), pyridine, pyrazole and pyrimidine derivatives (5-8). Also, compound 8 reacted with phosphorus-oxychloride in dimethyl formamide and p-flurobenzylidenemalononitrile to give formyl and pyrimidopyrimidene derivatives (10, 12). | ||
| Keywords | ||
| BENZOFURAN DERIVATIVES; Biological Activity | ||
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