assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).
abdel hamid, Y., Abdel Moniem, A., Khalifa, N., Elsafy, U. (2023). assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).. EKB Journal Management System, 29(1.2), 9-16. doi: 10.21608/zumj.2020.31650.1867
Yasser mustafa abdelazim abdel hamid; Ahmed Mohammed Abdel Moniem; Naglaa Khalifa; usama Roshdy Elsafy. "assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).". EKB Journal Management System, 29, 1.2, 2023, 9-16. doi: 10.21608/zumj.2020.31650.1867
abdel hamid, Y., Abdel Moniem, A., Khalifa, N., Elsafy, U. (2023). 'assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).', EKB Journal Management System, 29(1.2), pp. 9-16. doi: 10.21608/zumj.2020.31650.1867
abdel hamid, Y., Abdel Moniem, A., Khalifa, N., Elsafy, U. assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).. EKB Journal Management System, 2023; 29(1.2): 9-16. doi: 10.21608/zumj.2020.31650.1867

assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).

Zagazig University Medical Journal
Article 547, Volume 29, Issue 1.2, January 2023, Pages 9-16    PDF (269.35 K)
Document Type: Review Articles
DOI: 10.21608/zumj.2020.31650.1867
Authors
Yasser mustafa abdelazim abdel hamid* 1; Ahmed Mohammed Abdel Moniem2; Naglaa Khalifa3; usama Roshdy Elsafy2
1Department of pediatrics, Zagazig University hospitals, Egypt.
2pediatric-medicine-zagazig university-zagazig-Egypt
3Faculty of Medicine, Zagazig University, Department of Clinical Pathology, Sharkia, Egypt
Abstract
Abstract

Background: Bacterial sepsis is a life threatening crisis with high mortality and morbidity in neonates, Reliable marker is needed for the diagnosis of neonatal sepsis so that early treatment can be initiated. C-reactive protein (CRP), IL-6 can be used as Reliable markers for the diagnosis of neonatal sepsis so that early treatment can be initiated.
Aim of the work: to detect the levels of IL-6, CRP and HS-CRP in clinically suspected cases of neonatal sepsis and evaluation and analysis of these parameters as early markers of neonatal sepsis.
Patients and methods: A prospective cohort study was conducted on 60 neonates at neonatal intensive care unit of pediatric department and clinical pathology department at Zagazig university hospitals.
Results: IL-6 at a cut off value of 187.5Pg/ml had sensitivity of 87.5% and specificity of 63.6% with a negative predictive value of 93.3%. HS-CRP at a cut off value of 3.3 Mg/L had a higher sensitivity but a lower specificity at 100% and 47.7% repectively. CRP showed higher specificity than HS-CRP and IL-6 with 61.7% with a negative predictive value of 90%. A combination of IL-6 and CRP showed improvement of sensitivity to 100% and a negative predictive value of 100% and is more cost effective than the combination of IL-6 and HS-CRP which showed similar sensitivity and negative predictive value but showed less specificity
Conclusion: a combination of IL-6 and HS-CRP would be a sensitive test for early diagnosis of neonatal sepsis at a sensitivity of 100% and a similar NPV,
Keywords
Key words: neonatal sepsis; CRP; HS-CRP; IL-6; NPV. Early diagnosis
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