Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Invasive Ductal Carcinoma of the Breast | ||
| Sohag Medical Journal | ||
| Article 12, Volume 24, Issue 3, July 2020, Pages 81-87 PDF (1007.26 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/smj.2020.37789.1178 | ||
| Authors | ||
| Sheren FM Ahmed1; Nagwa Abd El-Sadek Ahmed* 2; Kamal A A Hassanein3; Eman Muhammad Salah EL-Deen4 | ||
| 1Pathology department, Faculty of medicine, Sohag university | ||
| 2Department of Pathology-Faculty of Medicine-Sohag Univeristy-Egypt | ||
| 3Depatyment of General Surgery Faculty of medicine Sohag Univetsity | ||
| 4Pathology Department, Faculty of Medicine, Sohag University | ||
| Abstract | ||
| Abstract Background and Aim: VCAM-1 (CD106) expressed mainly on activated endothelial cells in response to pro-inflammatory cytokines. Recent evidences suggest that it is closely correlated with tumor formation, angiogenesis and cancer progression. The aim of the current study was to evaluate expression status of VCAM-1 in mammary invasive ductal carcinoma (IDC), and to correlate its expression with some known clinicopathological data. Methods: Formalin-fixed paraffin embedded tissue blocks of 58 specimens of IDC were evaluated for VCAM-1 expression by immunohistochemistry (IHC). Correlation of VCAM-1 expression with different clinicopathological data was measured statistically. Results: Up-regulation of VCAM-1 expression was frequently observed in less differentiated tumors and within advanced stages with poor Nottingham prognostic index (NPI). VCAM-1 overexpression was significantly associated with the presence of lymph node metastasis (LNM), lymphovascular invasion (LVI), and prominent lymphocytic infiltration. There was no significant association of VCAM-1 expression with patients' age, tumor laterality, tumor size, muscle or skin invasion, and presence of in situ component. Conclusion: VCAM-1 molecule could promote LVI and LNM. VCAM-1 is a potential independent prognostic factor for breast carcinoma. | ||
| Keywords | ||
| VCAM-1; Breast carcinoma; IDC; CAMs; Tumor progression | ||
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