SYNTHESIS AND BIOLOGICAL EFFECT OF SOME THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE | ||
| Al-Azhar Bulletin of Science | ||
| Article 3, Volume 2006, Issue 6, June 2006, Pages 31-51 PDF (632.99 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/absb.2006.11638 | ||
| Authors | ||
| NADIA A. SMEISS* 1; NADIA M. SALEH1; FIVIAN F. NOFEL2; M. S. NASHWA1 | ||
| 1Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt. | ||
| 2Pharmacology Department, National Research Center, Cairo, Egypt. | ||
| Abstract | ||
| Interaction of thiophene enamino ester 1a,b with the acid chloride of p-tolyl sulphonamido-N-acetic acid derivatives 2a-cafforded the corresponding amide derivatives respectively 3a-f. Hydrazinolysis of 3a-f with hydrazine hydrate yielded 4a-f. Diazotization of 1a then coupling with different amines gave 6a,b. compounds 7a,b was afforded when diazonium chloride of p-toludin or enamino thiophene 3-carboxylate (5) was reacted with compound 1a. Air oxidation of 6a yielded 8. Coupling was carried out with different amines compounds where 5 yielded 9a,b. According to Gewald method 11a-b was prepared from reaction of 10a,bwith malononitrile, From 11a,bwe can prepare compounds 13, 14a-c, 15a-c 16a,b, 17a,b, 18, 19 and 20. The structure of these compounds was confirmed by infrared, mass, H-NMR spectra the biological activity of some compounds were discussed and found to be active. | ||
| Keywords | ||
| Biological effect; THIENO[2, 3-D] PYRIMIDINE-4-(3H) ONE | ||
|
Statistics Article View: 222 PDF Download: 297 |
||
