pH Assists For Selective Determination Of Acyclovir By The Emission Enhancement Of Tb3+Chemosensor In Tablet And Serum Samples | ||
| Egyptian Journal of Chemistry | ||
| Article 14, Volume 64, Issue 2, February 2021, Pages 713-720 PDF (602.59 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2020.40799.2826 | ||
| Authors | ||
| tarek ahmed amin1; mohamed emad azeb1; Mohamed Sabry Ahmed Abdel-Mottaleb2; Mohamed Said Attia* 3 | ||
| 1Chem. Dep., Fac. of Sci., Ain Shams Uni. | ||
| 2Department of Chemistry, Faculty of Science, Ain Shams University | ||
| 3Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt | ||
| Abstract | ||
| A new selective method for the determination of acyclovir in tablets and serum samples was developed. The method depends on the luminescence enhancement of Tb3+ chemo sensor with different concentrations of acyclovir at pH 10. Acyclovir can form a complex with Tb3+ ion of 1:3 molar ratio in DMSO. The luminescence intensity of Tb3+-acyclovir complex increases as the concentration of the drug increases at λex=320 nm, pH 10 in DMSO. The linear range for determination of the selected drug in DMSO 1.0 x 10-9 –1 x 10-5 mol L-1 the detection limits were 0.24 x 10-9 mol L-1. | ||
| Keywords | ||
| Acyclovir; Tb- Acyclovir complex; Luminescence intensity; Enhancement | ||
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