El-Sayed Mohamed El-Habibi; Magda Protective Effect of Date Palm Extracts on Cadmium-Induced Infertility in Male Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 1, Volume 69, Issue 4, October 2017, Pages 2181-2190 PDF (590.88 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0041514 | ||
| Authors | ||
| Mahmoud El-Komy; Heba Osama Saad* | ||
| Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| Background: Infertility is a problem which affects one in six couples. However, male factor considers solely responsible in about 20% of infertile couples and contributory in another 30–40%. Objective: The aim of this study was to elucidate the effect of date palm pollen (DPP) and date palm seed extract (DPS) on cadmium-induced infertility in male rats. Materials and Methods: Thirty six male albino rats were divided into six groups (n=6) and received their treatment orally for 30 days: group 1, control; group 2, (DPP): (240mg/kg) daily, group 3, (DPS): (100mg/kg) daily, group 4, (CdCl2): (5mg/kg) every other day, group 5, (CdCl2 + DPP): CdCl2 as group 4, followed by DPP as group 2 (each dose given 2 hours after CdCl2); group 6, (CdCl2 + DPS): CdCl2 as group 4, followed by DPS as group 3 (each dose was given 2 hours after CdCl2). Results: The current data exhibited significant decrease in the sperm quality, T, E2, FSH, LH, aromatase enzyme, TAC, GSH, SOD and CAT, with marked increase in MDA& XO and severe destruction in testis histoarchitecture in CdCl2 treated rats. However, there was a significant improvement in all these parameters with DPP& DPS administration. Conclusion: consumption of DPP or DPS might be considered as a functional treatment for retarding risks of infertility associated with cadmium exposure. | ||
Highlights | ||
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| Keywords | ||
| Male infertility; cadmium; date palm pollen; Date palm seed; antioxidants; testis | ||
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