Comparative Modelling, Toxicological and Biochemical Studies of Imidacloprid and Thiamethoxam Insecticides on the House Fly, Musca domestica L. (Diptera: Muscidae)

Abdel-Haleem, Doaa R.; Genidy, Noha A.; Fahmy, Adel R.; Abu- El Azm, Fatma S. M.; Ismail, Nasser S. M.

doi:10.21608/eajb.2018.11977

	Comparative Modelling, Toxicological and Biochemical Studies of Imidacloprid and Thiamethoxam Insecticides on the House Fly, Musca domestica L. (Diptera: Muscidae)
Egyptian Academic Journal of Biological Sciences. A, Entomology
Article 4, Volume 11, Issue 1, February 2018, Page 33-42 PDF (314.59 K)
DOI: 10.21608/eajb.2018.11977
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Authors
Doaa R. Abdel-Haleem¹; Noha A. Genidy¹; Adel R. Fahmy¹; Fatma S. M. Abu- El Azm²; Nasser S. M. Ismail³
¹Entomology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
²Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
³Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
Abstract
Neonicotinoid baits are recently replacing anticholinesterase baits for adult house fly (Musca domestica L.) control. Recently, imidacloprid (IMI) and thiamethoxam (THIA) are widely used for the control of this pest. In this study both compounds were docked to elucidate their interactions with acetylcholine binding protein (AChBP). The feeding technique was used to evaluate the toxicity of tested insecticides to adult house flies. Bioassay experiments showed that the THIA was more toxic to adult house flies than IMI with LC₅₀ values 7.27 and 21.08 ppm; respectively. The biochemical activities of acetylcholinesterase, ATPase, cytochrome P-450 and carboxylesterase were increased by insecticides treatment, while, the total protein content was reduced.
Keywords
Neonicotinoid baits; Anticholinesterases; House flies; (AChBP) and Docking


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