Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities
(2010). Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities. EKB Journal Management System, 53(2), 243-255. doi: 10.21608/ejchem.2010.1217
. "Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities". EKB Journal Management System, 53, 2, 2010, 243-255. doi: 10.21608/ejchem.2010.1217
(2010). 'Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities', EKB Journal Management System, 53(2), pp. 243-255. doi: 10.21608/ejchem.2010.1217
Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities. EKB Journal Management System, 2010; 53(2): 243-255. doi: 10.21608/ejchem.2010.1217

Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities

Egyptian Journal of Chemistry
Article 5, Volume 53, Issue 2, April 2010, Page 243-255  XML PDF (460.72 K)
DOI: 10.21608/ejchem.2010.1217
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Abstract
 
THE 2-DAIZO-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide cou coupled with either malononitrile or ethyl cyanoacetate to give the hydrazo derivatives 4a and 4b, respectively. The latter products underwent hetero-cyclization to give pyrazole, pyrimidine and pyridazine derivatives. The antimicrobial evaluation of the newly synthesized products was measured and most of the products showed interesting activities.
Keywords
Tetrahydrobenzo[b]thiophene; pyrazole; Pyrimidine and Pyridazine
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