Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities | ||
Egyptian Journal of Chemistry | ||
Article 5, Volume 53, Issue 2, April 2010, Pages 243-255 PDF (460.72 K) | ||
DOI: 10.21608/ejchem.2010.1217 | ||
Abstract | ||
THE 2-DAIZO-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide cou coupled with either malononitrile or ethyl cyanoacetate to give the hydrazo derivatives 4a and 4b, respectively. The latter products underwent hetero-cyclization to give pyrazole, pyrimidine and pyridazine derivatives. The antimicrobial evaluation of the newly synthesized products was measured and most of the products showed interesting activities. | ||
Keywords | ||
Tetrahydrobenzo[b]thiophene; pyrazole; Pyrimidine and Pyridazine | ||
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