The Effect of Oral Co-trimoxazole on Decreasing Bacterial Adherence and Biofilm Formation on Ureteral Stents Surfaces
Abdel-Kader, M., Mohamed, O., Alemam, M., El-Gelany, M., AbdelRazek, M. (2020). The Effect of Oral Co-trimoxazole on Decreasing Bacterial Adherence and Biofilm Formation on Ureteral Stents Surfaces. EKB Journal Management System, 3(1), 7-12. doi: 10.21608/svuijm.2020.123722
Mohammed S. Abdel-Kader; Omar Mohamed; Mohamed Alemam; Mohamed El-Gelany; Mostafa AbdelRazek. "The Effect of Oral Co-trimoxazole on Decreasing Bacterial Adherence and Biofilm Formation on Ureteral Stents Surfaces". EKB Journal Management System, 3, 1, 2020, 7-12. doi: 10.21608/svuijm.2020.123722
Abdel-Kader, M., Mohamed, O., Alemam, M., El-Gelany, M., AbdelRazek, M. (2020). 'The Effect of Oral Co-trimoxazole on Decreasing Bacterial Adherence and Biofilm Formation on Ureteral Stents Surfaces', EKB Journal Management System, 3(1), pp. 7-12. doi: 10.21608/svuijm.2020.123722
Abdel-Kader, M., Mohamed, O., Alemam, M., El-Gelany, M., AbdelRazek, M. The Effect of Oral Co-trimoxazole on Decreasing Bacterial Adherence and Biofilm Formation on Ureteral Stents Surfaces. EKB Journal Management System, 2020; 3(1): 7-12. doi: 10.21608/svuijm.2020.123722

The Effect of Oral Co-trimoxazole on Decreasing Bacterial Adherence and Biofilm Formation on Ureteral Stents Surfaces

SVU-International Journal of Medical Sciences
Article 3, Volume 3, Issue 1, January 2020, Pages 7-12    PDF (192.19 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2020.123722
Authors
Mohammed S. Abdel-Kader1; Omar Mohamed1; Mohamed Alemam2; Mohamed El-Gelany* 1; Mostafa AbdelRazek1
1Urology Department, Faculty of Medicine, South Valley University, Qena, Egypt
2Clinical and Chemical Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt
Abstract
Background: Double J ureteral stents have been widely used in urological practice. They are
liable to biofilm formation on their outer or inner surfaces.
Objectives: To assess the effect of oral co-trimoxazole on decreasing bacterial adherence and
biofilm formation on double J ureteral stent surfaces and subsequent post-operative urinary
tract infection.
Patients and methods: 109 patients undergoing double J ureteral stent insertion in our department
randomized into two groups group A (55 patients) not taking any antibiotics during
the indwelling time “control group” and group B (54 patients) on oral co-trimoxazole (2 TMP
mg/kg/day) during the indwelling time. Two weeks post double J stent insertion, urine analysis
was done for all patients and urine culture was done for patients with significant pyuria (WBCs
=> 20 by high power field). One-month post-operative, double J stent was removed anda segment
of about 3-5 cm is sent for culture. All results recorded and analyzed with Statistical
Package for Social Science® (SPSS) and Microsoft Excel 2010.
Results: 63.6% of group A (35 patients) were positive stent culture, while 37% of group B (20
patients) were positive stent culture. Escherichia coli was the organism most commonly isolated
from the stent culture in both groups.
Conclusion: This study shows that oral co-trimoxazole has a role on decreasing bacterial adherence
and biofilm formation on double J ureteral stent surfaces.
Keywords
Double J ureteral stents; Biofilm; Co-trimoxazole
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