Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children
Temsah, K., Mostafa, M., El-Khaleegy, H., El Rifai, A., Abd Raboo, M., Al shazly, S. (2021). Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children. EKB Journal Management System, 3(1), 922-929. doi: 10.21608/ijma.2020.46359.1192
Khaled Aly Temsah; Mostafa Elshahat Mostafa; Hany Abdul Hady El-Khaleegy; Atef Wahdan El Rifai; Mona Abd Raboo; Sherief M. Al shazly. "Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children". EKB Journal Management System, 3, 1, 2021, 922-929. doi: 10.21608/ijma.2020.46359.1192
Temsah, K., Mostafa, M., El-Khaleegy, H., El Rifai, A., Abd Raboo, M., Al shazly, S. (2021). 'Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children', EKB Journal Management System, 3(1), pp. 922-929. doi: 10.21608/ijma.2020.46359.1192
Temsah, K., Mostafa, M., El-Khaleegy, H., El Rifai, A., Abd Raboo, M., Al shazly, S. Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children. EKB Journal Management System, 2021; 3(1): 922-929. doi: 10.21608/ijma.2020.46359.1192

Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children

International Journal of Medical Arts
Article 4, Volume 3, Issue 1, January 2021, Page 922-929  XML PDF (1017.96 K)
Document Type: Original Article
DOI: 10.21608/ijma.2020.46359.1192
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Authors
Khaled Aly Temsah email 1; Mostafa Elshahat Mostafa1; Hany Abdul Hady El-Khaleegy2; Atef Wahdan El Rifai3; Mona Abd Raboo4; Sherief M. Al shazly5
1Department of Parasitology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
2Pediatrics Department, Damietta Faculty of Medicine, Al-Azhar University, Egypt
3Department of Chest Disease, Damietta Faculty of Medicine, Al-Azhar University, Egypt
4Department of Parasitology, Faculty of Medicine for Girls, Al-Azhar University, Egypt.
5Department of Neurology, Damietta Faculty of Medicine, Al-Azhar University, Egypt.
Abstract
Background: The link between parasitic infestation and allergic diseases or unexplained neurologic manifestations was hypothesized, especially in children. However, the debate continues regarding this link.
Aim of the work: To determine the seroprevalence of toxocariasis in children with different allergic diseases [bronchial asthma and skin allergy], besides the unexplained neurological manifestations [epilepsy and focal neurologic deficits] in children.
Patients and methods: Children with bronchial asthma [40 children], skin allergy [40 children], and unexplained neurological manifestations [epilepsy and focal neurologic deficits], [40 children] were included. All underwent a full history taking, clinical examination, lab investigations, and seropositivity determination for Toxocara canis.
Results:Eosinophilia was reported in 22.5%, 30.0%, and 17.5% of asthma, skin, and unexplained neurological manifestations groups, respectively. In patients with asthma, the prevalence of toxocariasis was 15.0%; in skin disease, it was 7.5%, and in unexplained neurological manifestations, it was 12.5%. There was no significant difference between positive and negative toxocariasis regarding patient demographics. But there was a significant increase in contact with pets, chronic urticaria, lymph nodes involvement, and eosinophilia in positive when compared to negative groups.
Conclusion: The association between Toxocara canis infection and allergic diseases such as bronchial asthma, chronic urticaria, and unexplained neurological manifestations [epilepsy and focal neurologic deficits] was confirmed in the present work. The contact with dogs and cats [pets] was the major determinant risk factor explaining such association. Prospective cohort studies were warranted to examine the cause-effect relationship.
Keywords
Bronchial asthma; Children; Toxocariasis; Epilepsy; Chronic urticaria
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