DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES
Sakr, H. (2015). DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES. EKB Journal Management System, 52(2), 82-100. doi: 10.21608/ajps.2015.12534
Helmy Sakr. "DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES". EKB Journal Management System, 52, 2, 2015, 82-100. doi: 10.21608/ajps.2015.12534
Sakr, H. (2015). 'DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES', EKB Journal Management System, 52(2), pp. 82-100. doi: 10.21608/ajps.2015.12534
Sakr, H. DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES. EKB Journal Management System, 2015; 52(2): 82-100. doi: 10.21608/ajps.2015.12534

DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES

Al-Azhar Journal of Pharmaceutical Sciences
Article 5, Volume 52, Issue 2 - Serial Number 52, September 2015, Pages 82-100    PDF (946.9 K)
Document Type: Original Article
DOI: 10.21608/ajps.2015.12534
Author
Helmy Sakr
Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
Abstract
The thermal condensation of 2,4-diamino 5-bromo-6-hydroxypyrimidine with 2-amino-3-mercaptopropylaniline derivatives (6)    and 2-amino-3-mercaptopropymethyllaniline derivatives (9) resulted in 2,4-diamino-6-substituted anilinomethlyl 6,7-dihydro-8H-pyrimido[4,5-b][1,4] thiazine derivatives (13, R= H) and 2,4-diamino-6-substituted methylanilinomethlyl 6,7-dihydro-8-methyl-pyrimido[4,5-b][1,4] thiazine derivatives (13, R= CH3) respectively. The synthesized compounds were screened for antimicrobial activity and it was found that the screened compounds have antimicrobial and antifungal activity comparable to chloramphenicol and terbinafine.
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