NEPHROPROTECTIVE EFFECT OF METFORMIN AGAINST GLYCEROL-INDUCED ACUTE KIDNEY INJURY IN RATS | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 6, Volume 52, Issue 2 - Serial Number 52, September 2015, Pages 101-113 PDF (442.95 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2015.12537 | ||
| Author | ||
| Amany Alzokaky | ||
| Pharmacology and Toxicology Department, Pharmacy College (girls), Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Rhabdomyolysis-associated acute kidney injury (AKI) is a serious life-threatening condition. Therefore, more effective strategies are needed for its prevention. The pathophysiological process of rhabdomyolysis-associated AKI involves oxidative stress, inflammation and apoptosis. Metformin (MF) has been known to possess antioxidant, anti-inflammatory and antiapoptotic properties. This study explored the possible effect of pretreatment with metformin on the development of glycerol-induced-AKI in rats. | ||
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