Anti-inflammatory activity in vitro and in vivo of ethanolic extracts of Stevia rebaudiana Bertoni and Trigonella foenum-graecum | ||
| Scientific Journal of Agricultural Sciences | ||
| Article 15, Volume 2, Issue 2, December 2020, Pages 137-143 PDF (968.32 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/sjas.2020.48817.1053 | ||
| Authors | ||
| Medhat I. El-Taib1; Gamal Fakhry* 2; Yasser Khalifa1; Haredy Haredy3 | ||
| 1Agronomy, Fac. Agric., Al-Azhar Univ., Assuit Branch | ||
| 2Faculty of Agriculture - Minia University | ||
| 3Pharmacology, Fac. of Medicine, Al-Azhar Univ., Assuit Branch | ||
| Abstract | ||
| This study was based on evaluating anti-inflammatory activities of ethanolic extracts from Stevia leaves (EESL) and Fenugreek seeds (EEFS) (in vitro and in vivo). In the in vitro experiment, the results exhibited potent anti-inflammatory activity. The combination of both extracts (1:1, 100 g) showed to be the most potent inhibitor of COX-2 with inhibition % (83.64%). This result was comparable with the standard Celecoxib showed higher level of inhibition, (86.63%, 100 g). While, EESL showed the highest activity as COX-1 inhibitory activity (74.35%, 100 g), which it is higher than standard Celecoxib (67.64%, 100 g). In vivo anti-inflammatory activity was performed on Wistar rats at the doses 200 and 400 mg/kg body weight using the carrageenan-induced rat paw edema modal. Combination of (SLEE + FSEE, each 100 mg) displayed the highest significant anti-inflammatory activity (0.46ef± 0.025, p < 0.05) after 4 h, compared with indomethacin (0.44f ± 0.025, p < 0.05). The results indicated that these plants may have a role for discovering new anti-inflammatory natural drugs. Furthermore, Stevia leaves and Fenugreek seeds can be subjected to further investigations as anticancer agents. | ||
| Keywords | ||
| Anti-inflammatory; COX-1; COX-2-isozyme; fenugreek- Stevia | ||
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