Natural History and Surgical Management of Oral Malignant Melanoma | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 12, Volume 69, Issue 8, October 2017, Page 3016-3020 PDF (264.13 K) | ||||
Document Type: Original Article | ||||
DOI: 10.12816/0042849 | ||||
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Authors | ||||
Rahmah Hameed Al Salman1; Mohammed Essam Fageha2; Khalid Abdulrahman S Alghamdi3; Suzan Sulaiman hamad Shamlan4; Alaa Omar D Almalki3; Wajdi Mohammed Bardisi5; Khaled Hamad M Albaradi6; Majid Gais Faisal Alsharif7; Yara Tareq Mohammed Talab4 | ||||
1Alfarabi College | ||||
2Al-Farabi College for Nursing and Dentistry | ||||
3ordan university of Science and technology | ||||
45th years general dentist on batterjee medical college | ||||
5umm al-qura university faculty of dentistry | ||||
6Intern in KAU | ||||
7Batterjee medical college | ||||
Abstract | ||||
Pigmented entities are relatively common in the oral mucosa and arise from intrinsic and extrinsic sources. Conditions such as melanotic macules, nevi, smoker's melanosis, amalgam and graphite tattoos, racial pigmentation, and vascular blood-related pigments occur with some frequency. Addison disease, Peutz-Jeghers syndrome, and Laugier-Hunziker syndrome also appear in perioral and oral locations as pigmented macules. Detailed knowledge of melanoma at the molecular level allows the development of new treatment alternatives and to design effective new drugs. Addison disease presents as adrenal cortical hypofunction along with splotchy or generalized bronzing of the mucosa and skin. Peutz-Jeghers syndrome has periorificial freckling along with hamartomatous intestinal polyps, and, as a differential diagnosis, Laugier-Hunziker syndrome presents with macular mucocutaneous hyperpigmentation and melanonychia with no known systemic disease association. We conducted this review using a comprehensive search of MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials from January 1, 1970, through February 28, 2017. | ||||
Keywords | ||||
Malignant Melanoma; oral mucosa; Immunotherapy | ||||
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