Evaluation of Serum Angiopoietin-2 in Children and Adolescents with Sickle Cell Disease | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 12, Volume 68, Issue 1, July 2017, Pages 899-903 PDF (540.47 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0038189 | ||
| Authors | ||
| Nevine G. Andrawes1; Eman A. Ismail2; Maged Maher Salib Roshdy3; Amna Mohamed Ibrahim1 | ||
| 1Pediatrics department , Faculty of Medicine, Ain Shams University | ||
| 2Clinical PathologyDepartments, Faculty of Medicine, Ain Shams University | ||
| 3Opthalmology Departments, Faculty of Medicine, Ain Shams University | ||
| Abstract | ||
| Background: A pro-angiogenic state has been found in adults with sickle cell disease (SCD), mainly because of elevated angiopoietin-2 levels. Aim of the work was to determine the level of Angiopoietin-2 in children and adolecents with SCD and assess its relation to markers of hemolysis and iron overload. Methods: Forty SCD patients in steady state were studied focusing on hydroxyurea therapy, hematological profile and serum ferritin. Patients were compared to 40 healthy controls. Results: Angiopoietin-2 levels were significantly higher in SCD patients compared with healthy controls (8506.3 ± 3789.5 pg/mL versus 2791.7 ± 1263.6 pg/mL; p<0.001). Angiopoietin-2 levels were significantly higher in SCD patients with cardiopulmonary complications. Significant positive correlations were found between serum angiopoietin-2 levels and age as well as HbS. Conclusions: Elevated angiopietin-2 levels in SCD highlights the role of angiogenesis in the pathophysiology of SCD. Angiopoietin-2 may be considered a promising risk marker for screening of SCD patients at risk of cardiopulmonary complications. | ||
| Keywords | ||
| Serum Angiopoietin-2; children; Adolescents; Sickle Cell | ||
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