Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity | ||
| Journal of Advanced Pharmacy Research | ||
| Article 3, Volume 5, Issue 1, January 2021, Pages 202-210 PDF (506.43 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/aprh.2020.49788.1120 | ||
| Authors | ||
| Hend Medhat El-Shanbaky* ; Rania Abd El-Hameed; Mosad Sayed Mohamed | ||
| Pharmaceutical Organic Chemistry Department, Faculty of pharmacy, Helwan University, Helwan, Cairo, Egypt | ||
| Abstract | ||
| Objective: The aim of the present study is to synthesize novel 2-furanones due to their biological activities and also their ability to be converted to several biologically active heterocyclic and non-heterocyclic compounds. Methods: Two novel 2-furanone derivatives were synthesized and used to prepare fourteen heterocyclic and non-heterocyclic compounds. Structures of all the newly synthesized compounds were confirmed by elemental and spectral analysis including Mass, IR and 1H-NMR spectroscopy. Evaluation of antiviral activity of selected examples of the obtained compounds was performed using two gastroenteric viruses: adenovirus and rotavirus. Results: Two pyridazinone derivatives namely; 3-(3,4-Dichlorophenyl)-5-[(2-methoxypheny)l-methyl]-1H-pyridazin-6-one (7a) and 3-(3,4-Dichlorophenyl)-5-[(4-fluropheny)l-methyl]-1H-pyridazin-6-one (7b) showed high activities against rotavirus. Conclusions: Compounds 7a and 7b can be considered as promising anti-rotaviral agents needing further investigations and clinical studies. | ||
| Keywords | ||
| Furanone; Hydrazide; Pyridazinone; Rotavirus; Adenovirus | ||
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