Sirt-1 as A Predictive Marker of Metabolic Syndrome in Psoriasis Patients
sabry, H., Hamed, A., El Fallah, A., Ghonamey, A. (2020). Sirt-1 as A Predictive Marker of Metabolic Syndrome in Psoriasis Patients. EKB Journal Management System, 5(Issue 7 part (1) - (2)), 15-17. doi: 10.21608/bjas.2020.137383
H.H. sabry; A.M. Hamed; A.A. El Fallah; A.R. Ghonamey. "Sirt-1 as A Predictive Marker of Metabolic Syndrome in Psoriasis Patients". EKB Journal Management System, 5, Issue 7 part (1) - (2), 2020, 15-17. doi: 10.21608/bjas.2020.137383
sabry, H., Hamed, A., El Fallah, A., Ghonamey, A. (2020). 'Sirt-1 as A Predictive Marker of Metabolic Syndrome in Psoriasis Patients', EKB Journal Management System, 5(Issue 7 part (1) - (2)), pp. 15-17. doi: 10.21608/bjas.2020.137383
sabry, H., Hamed, A., El Fallah, A., Ghonamey, A. Sirt-1 as A Predictive Marker of Metabolic Syndrome in Psoriasis Patients. EKB Journal Management System, 2020; 5(Issue 7 part (1) - (2)): 15-17. doi: 10.21608/bjas.2020.137383

Sirt-1 as A Predictive Marker of Metabolic Syndrome in Psoriasis Patients

Benha Journal of Applied Sciences
Article 4, Volume 5, Issue 7 part (1) - (2), October 2020, Pages 15-17    PDF (680.55 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2020.137383
Authors
H.H. sabry1; A.M. Hamed1; A.A. El Fallah2; A.R. Ghonamey3
1Dermatology,Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Clinical and Chemical Pathology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
3Dermatology,Venereology and Andrology Dept., Al.Houd Almarsoud hospital , Cairo , Egypt
Abstract
Psoriasis affects mainly skin, nails and joint and is characterized by the presence of sharply demarcated, red plaques with adherent silvery white scales and a tendency for symmetrical distribution over the body. Psoriasis can be provoked by external and internal triggers, including mild trauma, sunburn, infections, systemic drugs and stress. There is a strong positive association between psoriasis and known risk factors including central obesity, insulin resistance and dyslipidemia. Sirt-1 is a NAD+-dependent deacetylase involved in the regulation of a myriad of cellular processes including mitochondrial biogenesis, genomic stability, cellular senescence and apoptosisAim: The aim of this study was to assess serum levels of sirt-1 in psoriasis patients and correlate their levels with the severity of the disease.. Method: This present study included: Patient group (group 1) included 25 psoriasis patients. In addition, 15 apparently healthy, age and sex matched individuals included as a control group (Group 2). All were investigated for serum sirt 1 level and compared. Serum Sirt 1 were estimated using commercially available ELISA kits. Conclusion: From the results of present study, it is concluded that sirt 1levels are lower in psoriasis patients not corrospnding to the disease severity.
Keywords
Psoriasis; Metabolic syndrome; Sirt 1
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