Cardiotoxicity of Naja nubiae snakebites: A review and consideration | ||||
| Records of Pharmaceutical and Biomedical Sciences | ||||
| Article 2, Volume 5, Pharmacology-Pharmaceutics, January 2021, Page 14-20 PDF (346.67 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/rpbs.2019.18479.1044 | ||||
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| Authors | ||||
Mohammed Elsayed M.   1; Mona El-Azab 2; Yasser Mostafa 3; Tarek Rahmy4
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| 1Pharmacology and toxicology, Faculty of Pharmacy, Suez canal University, Ismailia, Egypt | ||||
| 2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt | ||||
| 3Pharmacology and Toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. | ||||
| 4Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt | ||||
| Abstract | ||||
| Snake bites are considered as one of the serious challenges facing people living in areas near the place of those snakes’ habitat. Antivenin treatment though being the gold standard against expected toxicities, is not always present especially when toxicology centers are out of reach during cases of acute envenomation and injuries. Nubian spitting cobra or Naja nubiae is known to be major threat of hematological and cardiac toxicities in Upper Egypt. Although the main characteristic of its venom is being neurotoxic, cardiotoxicity due to high content of cardiotoxins and generation of reactive oxygen species is profound in cases of toxicity by envenomation. This review highlights the structure of cardiotoxins as the main component of Naja nubiae venom and lists different possible cardiotoxicities associated with it especially myocardial infarction and myocarditis. As well as possible future recommendations for those who are in risk of inhabiting or travelling to where these snakes are found. | ||||
| Keywords | ||||
| Naja nubiae; Cardiotoxins; Myocardial infarction; Myocarditis | ||||
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