Immune -Toxicity of Synthetic Pyrethroids: Modulation of Cypermethrin and Permethrin Toxicity by Tamoxifen | ||||
| Delta Journal of Science | ||||
| Article 2, Volume 36, Issue 3, December 2013, Page 123-138 PDF (1.01 MB) | ||||
| Document Type: Research and Reference | ||||
| DOI: 10.21608/djs.2013.139584 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| I. A. El Elaimy1; M. F.F. Bayomy1; T. A. Salem2 | ||||
| 1Faculty of Science, Minufiya University | ||||
| 2Genetic Engineering and Biotechnology Institute, Minufiya University | ||||
| Abstract | ||||
| Cypermethrin and permethrin are widely used in the agriculture in many countries. Continuous low level exposure of human to such chemicals may increase the susceptibility to various diseases due to the suppression of immune system. Therefore, the aim of the present study is to evaluate the toxicity of these pesticides at immunological, hematological and biochemical levels using tamoxifen as a modulatory agent against the toxicity of pyrethroids. The animal groups were intoxicated for 30 or 60 days with either cypermethrin or permethrin. The single effects of either pyrethroids or tamoxifen were studied. The double effects of both of tamoxifenpyrethroids were also investigated. It was found that pyrethroids alone decreased IgG level, while tamoxifen and tamoxifen plus pyrethroids increased its concentration. Pyrethroids, tamoxifen and tamoxifen in combination with pyrethroids had an inhibitory effect on lymphocyte stimulation index measured in vitro, phagocytic function of neutrophil and catalase activity. These treatment, however, increased relative ear thickness and contact hypersensitivity. In conclusion, these results raise some concerns about the possibility that tamoxifen may potentiate or attenuate the effects caused by pyrethroids. | ||||
| Keywords | ||||
| cypermethrin; permethrin; tamoxifen; lymphocyte; phagocytosis; IgG | ||||
|
Statistics Article View: 143 PDF Download: 247 |
||||
