Electrophysiological protective and therapeutic efficacy of resveratrol against cadmium chloride: An in vitro study | ||||
| Delta Journal of Science | ||||
| Article 5, Volume 36, Issue 2, June 2013, Page 24-37 PDF (1.2 MB) | ||||
| Document Type: Research and Reference | ||||
| DOI: 10.21608/djs.2013.139628 | ||||
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| Authors | ||||
| Hagar E Mohammed1; Sherifa H. Ahmed2; Zohour I Nabil3 | ||||
| 1Geological and biological Department, Faculty of Education, Suez Canal University, Al-Arish, Egypt | ||||
| 2Zoology Department, Faculty of Applied Sciences, Port Said University, Port Said, Egypt | ||||
| 3Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt | ||||
| Abstract | ||||
| Resveratrol (trans-3,4',5-trihydroxystilbene- RES), is a natural antioxidant found in various fruits and vegetables and is abundant in grapes. It has beneficial effects against coronary heart diseases. This study aims to explore the protective and therapeutic effects of resveratrol on cadmium chloride induced toxicity on isolated toad's hearts. Electrocardiogram (ECG) was recorded before and after direct perfusion of cadmium chloride (CdCl2) and resveratrol. Application of CdCl2 (2mM/L) into isolated toad's heart significantly decreased the heart rate (HR) accompanied by an elongation in the conduction time (P-R interval), while a non significant decrease of the ventricular contraction (R-wave amplitude) was observed within minutes (5-30 min) of CdCl2 application into isolated toad's. Pretreatment of isolated toad's hearts with RES (21μM/L) five min before CdCl2 application abolished the severe bradycardia and negative inotropic effect induced by CdCl2, this was accompanied by improvement of cardiac disorders induced by this toxic heavy metal. While, post treatment of RES after appearance of cardiac abnormalities induced by CdCl2 didn’t affect these induced disorders. In conclusion, the obtained investigation indicates that RES could serve as a protective agent against some of acute ( CdCl2) toxicity on isolated toad's heart than more that its therapeutic efficacy. However, low level of resveratrol at was not effective in preventing either neither sever bradycardia nor in reducing ventricular dysfunction induced by cadmium. | ||||
| Keywords | ||||
| Resveratrol; cadmium toxicity; Cardiac muscle; Electrophysiology | ||||
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