The Adjuvant Protective Effect of Resveratrol on Cisplatin-Induced Liver Toxicity in Male Albino Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 28, Volume 82, Issue 1, January 2021, Pages 164-173 PDF (914.47 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.139651 | ||
| Authors | ||
| Huda I. Abd-Elhafiz; Noha M. Issa* | ||
| Abstract | ||
| Background: Cisplatin is antineoplastic drug associated with hepatotoxicity due to oxidative stress. Resveratrol has antioxidant effect so it could protect the liver cell. Objective: the aim of this work was to investigate the possible protective effects of resveratrol on hepatotoxicity caused by cisplatin drug in rats. Materials and Methods: forty male albino rats were randomly divided into four groups: group I (control group): was maintained throughout the experiment without any treatment. Group II (resveratrol group) that received resveratrol daily in a dose of 25 mg/kg intraperitoneally for 21 days. Group III (cisplatin group) that received single intraperitoneal injection of cisplatin in a dose of 7.5 mg/kg at the 16th day of the experiment. Group IV (protected group) that received resveratrol in a dose of 25 mg/kg intraperitoneally for 21 days and cisplatin at 16th day of the experiment. Body and liver weight were estimated, biochemical measurements and histopathological study of the liver tissue were done. Results: showed significant preservation of the liver function and histological structure. Conclusion: it is concluded that resveratrol could protect liver against cisplatin side effects. | ||
| Keywords | ||
| Cisplatin; Liver toxicity; Resveratrol | ||
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