Some Chemical Aspects of 1,2,4-triazine derivatives
El-Barbary⃰, A., Sharaf, A., E-Bader, B. (2016). Some Chemical Aspects of 1,2,4-triazine derivatives. EKB Journal Management System, 37(1), 73-85. doi: 10.21608/djs.2016.139921
A. A. El-Barbary⃰; A. M. Sharaf; Bader E-Bader. "Some Chemical Aspects of 1,2,4-triazine derivatives". EKB Journal Management System, 37, 1, 2016, 73-85. doi: 10.21608/djs.2016.139921
El-Barbary⃰, A., Sharaf, A., E-Bader, B. (2016). 'Some Chemical Aspects of 1,2,4-triazine derivatives', EKB Journal Management System, 37(1), pp. 73-85. doi: 10.21608/djs.2016.139921
El-Barbary⃰, A., Sharaf, A., E-Bader, B. Some Chemical Aspects of 1,2,4-triazine derivatives. EKB Journal Management System, 2016; 37(1): 73-85. doi: 10.21608/djs.2016.139921

Some Chemical Aspects of 1,2,4-triazine derivatives

Delta Journal of Science
Article 8, Volume 37, Issue 1, June 2016, Pages 73-85    PDF (1.16 M)
Document Type: Research and Reference
DOI: 10.21608/djs.2016.139921
Authors
A. A. El-Barbary⃰; A. M. Sharaf; Bader E-Bader
Chemistry Department, Faculty of Science, Tanta University, Egypt
Abstract
Condensation of 3a,b with some aromatic aldehydes afforded the Schiff bases (4a-f). Reaction of 3a,b with
aromatic aldehydes and alkyl phosphites gave the corresponding amino phosphonates (5a-d). Heating 3a,b with 6a-f in POCl3 at
85 °C furnished the amino sulphonamides (7a- l). Acid hydrolysis of compounds 7a,b and 7k) furnished the amines (8a-c).
Condensation of 3a, b with 9a,b afforded the cyclized product (10a,b). Reaction of 3a with halo esters afforded 12 and 13.
Heating 3a,b with 14a-c afforded 15a-f. Hydrolysis of 15a,b afforded 16a,b. Fusion of 3a,b with 1,4-butane sultone gave sultams
(18a,b). The antimicrobial activity o9f some products was tried
Keywords
1; 2; 4-triazines; aldehydes; aminophosphonates; sultams; biological activity
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