Effect of Letrazol on External Malformation And Histopathological Changes In Mice Mus mucluse Fetus Brain | ||
| Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry | ||
| Article 4, Volume 8, Issue 1, June 2016, Pages 25-33 PDF (826.62 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsd.2016.14105 | ||
| Authors | ||
| H. H. Hantoosh; Hana Khalil Ismail; G. H. Abd-Eftah | ||
| Depatment of biology, College of science, Mosul University, Mosul, Iraq | ||
| Abstract | ||
| Present study carried out to investigate the effect of letrazol on congenital malformation, and histopathological change in mice fetus brain, 32 pregnant albino mice were divided into 3 equal groups then letrazol were administrated by cavage in different concentration (2.5,5,7) mg/kg at7th to the 18th day of gestation. The results showed That malformation reach to100%at 7mg/kg body weight it represented as a cleft lip exophthalmia eye, lose eyes shortening of the fore limbs, the tail malformation, Microscopically histological lesions of fetus brain shows an infiltration of inflammatory cells, necrosis and vocal degeneration. | ||
| Keywords | ||
| Letrazol; congenital malformation; Histopathological change; mice fetus brain | ||
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