PHARMACODYNAMIC INTERACTION BETWEEN NIFEDIPINE AND SODIUM VALPROATE AGAINST KAINIC ACID-INDUCED CONVULSOINS IN MICE دراسة التفاعالت الديناميکية الدوائية بين عقارى النيفيديبين وفالبروات الصوديوم ضد النوبات الصرعية المحدثة بمادة حامض الکاينيک فى الفئران

REFRENCES :
1-Katzung, B.G.: Basic and Clinical
Pharmacology 6th ed. Prentice Hall.
International Inc. London, UK, 1994, PP.
180.
2-Kryzhanovskii, G.N., Karpova, M.N.,
Abrosimov, U.V., Pankov, Olu., and
Lakinina, M.V.: Anticonvulsant activity of
sodium valproate and various calcium
antagonists during their combined use in
mice. Bull. Eksp. Biol. Med., 115(3): 231
(1993).
3-Tussel, J.M., Barron, S., and Seatosa, J.
Anticonvulsant activity of
delta-HcH-calcium-channel blockers and
calmodulin antagonists in seizures induced
by lindane and other convulsant drugs. Brain
Research, 17, 622 (1-2): 99-104 (1993).
4-Gasior, M., Kaminski, R., Brudniak, T.,
Kleinron, Z. and CzucZwar, S.J: Influence of
nicardipine, nimodipine and flunatizine on
the anticonvulsant efficacy of antiepileptics
against pentylenetetazole in mice. J. Neurol.
Transm. Gen. Sect. 103(7): 819-831(1996).
5- Jagiello-Wojtowicz, E., CzucZwar, S.J,
Chodkowska, A., Szponar, J. and Kleinrok,
z.: Influence of calcium channel blockers on
pentylenetetrazole and electroshock-induced
convulsions in mice. Poland. J. of Pharm.
and Pharmacol., 43,95-101(1991).
6-Palmer, G.C, Stagnitto, M.L., Ray, R.K.
Knowles, M.A., Harvery R. and Garske, G.E.
Anticonvulsant properties of calcium channel
blockers in mice. Epilepsia, 34 (2):
372-380(1993).
7-Kamal, J.A., Nadig, R.S., Joseph, T. and
David, J. : Effect of calcium channel blockers
on experimentally-induced seizures in rats.
Ind. J. of Exp. Bio., 28 (7): 605-608 (1990).
8-Wong, W.S. and Rahwan, R.G. Examination
of the potential antiepileptic activity of
calcium antagonists with diffe-rent sites of
action. Gene. Pharmacol. 20(3): 309-312
(1989).
9-Karpova, M.N.; Pankov, O.K., Gelbov, R. N.,
Germane, S.K., Klusha, V.E. and Duburg,
L.A. effect of calcium channel blocker
ryodipine on focal and generalized epileptic
activity Bull. Eskp. Biol. Med. 108 (11) :
553-555 (1989) .
10-CzucZwar S.J., Chodkowska, A., Kleinrok,
Z., Malex, U., and Jagillo-Wojtowicz, E.:
Effect of calcium channel inhibitors upon the
efficacy of common antiepileptic drugs.
Europ. J. of Pharmacol., 25, 126(1): 75-83;
(1990 (a)).
11-CzucZuar, S.J, Malex, U. and Kleinrok, Z.:
Influence of calcium channel inhibitors upon
the anticonvulsant efficacy of common
antiepileptics against 

pentylenetetrazole-induced convulsions in
mice. Neuro., 29 (10): 943-948 (1990 b).
12-Gram, A. and Bentsen, K.: Valproate: An
updated review. Acta Neurologica Scand.,
72: 129-139 (1985).
13-Chambon, J.P., Molimard, J.C., Calassi, R.,
Maruani, J., Rodier, D., Sigault G., Leyris,
R., Roncucci, R. and Biziere K.:
Anticonvulsant activity of
4,9-Dioxo-5,10-diazatetradecane (CM 40140),
a new GABA derivative, in mice and
photosensitive baboons. Arzneimettel
Forshung/Drug Res., 34 (II): 1017-1021
(1984).
14-Snedcor, G. and Cochran, W.: Statistical
Methods, 6th ed. Iowa state University Press,
Iowa, USA (1967).
15-Lotherman, E.W., Collins, R.C. and Ferren
delli, J.A.: Kainic acid-induced limbic
seizures: Electrophysiologic studies.
Neurology, 31: 806-812(1981).
16-Mubhof, U., Madeja, M. Bolms-Funke, P.,
Speckmann, E.J: Effects of epileptogenic
agent bicuculline methoidide on membrane
currents induced by N-methyl -D- aspartate
and kainate. Brain Res., 639: I 35-138:
(1994).
17-Lux, H.D. and Heinemann, U.: Ionic changes
during experimentally -induced seizure
activity. Electroencephalograph and Clinical
Neurophysiology (suppl.), 34: 289-297 (1978).
18-Rutecki, P.A., lebeda, F.J. and Johnston, D.:
Epileptiform activity induced by changes in
extracellular potassium in hippocampus. J.
of Neurophysiol, 54(5): 1363-1374: (1985).
19-Kudo, Y. and Ogura, A: Glutamate-induced
increase in intracellular calcium
concentration in isolated hippocampal
neurons. Bri. J. of Pharmacol., 89(1): 191-198
(1986).
20-Walden, J., Straub, H. and Speckmann, E.J.:
Epileptogenesis: Contribution of calcium
ions to the generation of epileptic activity
and antiepileptic calcium antagonism.
Neuropsychobiology, 27(3): 122-126 (1993).
21-Speckmann, E.J., Straub, H., Kohling, R.:
Contribution of calcium ions to the
generation of epileptic activity and
antiepileptic calcium antagonism.
Neuropsychobiology, 27(3): 122-126 (1993).
22-Shibuya, T. and Watanabe Y. : Central
effects of calcium channel blockers: multiple
sites of action, Nippon-Yakurigaku-Zasshi,
100(3): 239-247 (1992).
23-Ene, H.D., Williamson, P.J., Roberts, J.C.,
and Waddel, C.G: The natriuresis following
oral administration of the calcium
antagonists nifedipine and nitrendipine. Br.
J. of Clin. Pharmacol., 19: 423-427 (1985).