Expression of Discoidin Domain Receptor 2 in Colorectal Carcinoma: An Immunohistochemical Study | ||
| Zagazig University Medical Journal | ||
| Article 25, Volume 29, Issue 2.1, March and April 2023, Pages 322-328 PDF (622.44 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2021.45870.1967 | ||
| Authors | ||
| Rana Ahmed Ghareeb* 1; Magda Ibrahim Assaf2; Naglaa Ali Ramadan3; Ola A. Harb4 | ||
| 1pathology department, faculty of medicine, zagazig university, Egypt | ||
| 2Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| 3Pathology department, Faculty of medicine, Zagazig university, Egypt. | ||
| 4zagazig university Egypt | ||
| Abstract | ||
| Background: Colorectal cancer (CRC) is considered a highly fatal disease. There is a strong need for novel markers to reach a proper outcome. Discoidin domain receptor 2 (DDR2) belongs to the family receptors tyrosine kinases with a possible relation towards CRC,as DDR2 has a proved role in development of other cancers by enhancing proliferation and metastasis. Aim of the study: To evaluateDDR2 protein expression and its possible role in CRC for improved patient outcome and decreased morbidity and mortality. Material and methods: Forty-eight patients diagnosed as colorectal carcinoma were encountered in this study.We analyzed the immunohistochemical expression of discoidin domain receptor 2 and then assessed the correlation of its expression with clinicopathological data. Results: Discoidin domain receptor 2 expression is significantly associated with tumor size, infiltrating tumor border, presence of necrosis, tumor grade, tumor stage, lymphocytic infiltration and peritoneal spread (P=0.002, P=0.001, P=0.001, P=0.01, P=0.005, P=0.001, P=0.001, respectively), which all are associated with well-known indicators of poor prognosis. Conclusion: Discoidin domain receptor 2 overexpression, being correlated with poor prognostic factors in colorectal carcinoma, confirm the role of DDR2 in poor outcome. | ||
| Keywords | ||
| CRC; discoidin domain receptor 2; DDR2; immunohistochemical; prognostic | ||
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