Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines | ||
| Egyptian Journal of Chemistry | ||
| Article 9, Volume 54, Issue 5, October 2012, Pages 691-701 PDF (297.45 K) | ||
| DOI: 10.21608/ejchem.2011.1435 | ||
| Abstract | ||
| ASERIES of new 6,7,8,9-tetrahydrodibenz[ b,f][1,4]oxazepin-11(10H)-ones (3) was prepared by alkylation of salicylamides 1 with 2-chlorocyclohexanone followed by cyclodehydration of the resulting 2-cyclohexyloxybenzamides 2. New pyrido [2,3-b] [1,4]benzoxazepin-6(5H)-ones (8) were prepared by reacting salicoyl chlorides 4 or their corresponding acids 5 with 3-amino-2-chloropyridines 6 followed by treatment of the resulting amides 7 with sodium methoxide. Some of the new compounds were subjected to preliminary screened for their tranquilizing effect. | ||
| Keywords | ||
| Dibenz[b; f][1; 4]oxazepin-11(10H)-ones; Pyrido [2; 3-b] [1; 4] benz- oxazepin-6(5H)-ones; Tranquilizers and Diazepam | ||
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