Hypolipidemic and Hypoglycemic Effect of Cinnamon Extract in High Fat Diet Fed Rats
Mohammed, H., Abdel Fattah, D. (2018). Hypolipidemic and Hypoglycemic Effect of Cinnamon Extract in High Fat Diet Fed Rats. EKB Journal Management System, 46(2), 160-167. doi: 10.21608/zvjz.2018.14389
Haiam A. Mohammed; Doaa M. Abdel Fattah. "Hypolipidemic and Hypoglycemic Effect of Cinnamon Extract in High Fat Diet Fed Rats". EKB Journal Management System, 46, 2, 2018, 160-167. doi: 10.21608/zvjz.2018.14389
Mohammed, H., Abdel Fattah, D. (2018). 'Hypolipidemic and Hypoglycemic Effect of Cinnamon Extract in High Fat Diet Fed Rats', EKB Journal Management System, 46(2), pp. 160-167. doi: 10.21608/zvjz.2018.14389
Mohammed, H., Abdel Fattah, D. Hypolipidemic and Hypoglycemic Effect of Cinnamon Extract in High Fat Diet Fed Rats. EKB Journal Management System, 2018; 46(2): 160-167. doi: 10.21608/zvjz.2018.14389

Hypolipidemic and Hypoglycemic Effect of Cinnamon Extract in High Fat Diet Fed Rats

Zagazig Veterinary Journal
Article 9, Volume 46, Issue 2, June 2018, Page 160-167  XML PDF (628.96 K)
Document Type: Original Article
DOI: 10.21608/zvjz.2018.14389
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Authors
Haiam A. Mohammed email 1; Doaa M. Abdel Fattah2
1Physiology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt, 44511
2Biochemistry Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt, 44511
Abstract
The purpose of this study was to evaluate the effects of oral administration of cinnamon extract (CE) in rats fed on high fat diet (HFD). Thirty two adult male albino rats were divided into four groups; control group, HFD group, HFD group treated by cinnamon and the last group was treated with cinnamon extract. In HFD group, rats were fed on HFD for two months. In HFD group treated by cinnamon, rats fed on HFD for two months then CE was orally administered for a period of 4 weeks at a dose of 200 mg/kg body weight. In CE treated group, rats were fed on standard diet for two months then orally administered CE for a period of 4 weeks at a dose of 200 mg/kg body weight. The obtained results indicated that the oral administration of cinnamon extract has antihyperlipidemic effect that improving the lipid profile. There were reductions in the levels of serum triglycerides, LDL-C, VLDL-C (P≤ 0.01) and total cholesterol (P<0.05) with an increase of the HDL-C serum level (P≤ 0.01) in HFD fed rats treated by CE. There was a significant decrease in blood glucose level (P≤ 0.01), elevation of serum insulin level (P≤ 0.01) and reduction in liver enzyme ALT and AST activities (P≤ 0.01) with oral administration of CE. In addition, CE can promote glucose transporter isotype-4  (GLUT4) gene expression in adipose tissue of HFD fed rats. From the current study, it was concluded that oral administration of cinnamon extract has both hypolipidemic and hypoglycemic effects in hyperlipidemic rats.
Keywords
Cinnamon extract; High fat diet; Lipid profile; Insulin; GLUT4
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