Biochemical Study on Lymphocyte Cell Surface Antigen in Hepatitis C Infected Patients
Taha, M., Ezzat, M., Abd Elshafai, S., Khalifa, N., Elsayed, R. (2017). Biochemical Study on Lymphocyte Cell Surface Antigen in Hepatitis C Infected Patients. EKB Journal Management System, 9(1), 33-40. doi: 10.21608/eajbse.2017.14474
Mamdouh A.M. Taha; Mostafa Ahmed Ezzat; Shahira Abd Elshafai; Noha Khalifa; Rasha Elsayed. "Biochemical Study on Lymphocyte Cell Surface Antigen in Hepatitis C Infected Patients". EKB Journal Management System, 9, 1, 2017, 33-40. doi: 10.21608/eajbse.2017.14474
Taha, M., Ezzat, M., Abd Elshafai, S., Khalifa, N., Elsayed, R. (2017). 'Biochemical Study on Lymphocyte Cell Surface Antigen in Hepatitis C Infected Patients', EKB Journal Management System, 9(1), pp. 33-40. doi: 10.21608/eajbse.2017.14474
Taha, M., Ezzat, M., Abd Elshafai, S., Khalifa, N., Elsayed, R. Biochemical Study on Lymphocyte Cell Surface Antigen in Hepatitis C Infected Patients. EKB Journal Management System, 2017; 9(1): 33-40. doi: 10.21608/eajbse.2017.14474

Biochemical Study on Lymphocyte Cell Surface Antigen in Hepatitis C Infected Patients

Egyptian Academic Journal of Biological Sciences, E. Medical Entomology & Parasitology
Article 4, Volume 9, Issue 1, December 2017, Pages 33-40    PDF (219.33 K)
Document Type: Original Article
DOI: 10.21608/eajbse.2017.14474
Authors
Mamdouh A.M. Taha1; Mostafa Ahmed Ezzat2; Shahira Abd Elshafai2; Noha Khalifa2; Rasha Elsayed3
11-Department of Chemistry, Faculty of Science, Fayoum University.
22-Faculty of Medicine, Fayoum University
33-Fayoum University Hospital
Abstract
The current study aimed at assessment of peripheral blood lymphocyte cells in hepatitis C patients compared to Healthy controls and evaluating the potential diagnostic role and relation to disease severity and complications.
Patients and Methods: The present study included 27 hepatitis C patients and 27 healthy controls. Full history and clinical assessment of hepatitis C were performed for patients. Blood samples were collected from patients and controls for estimation of laboratory parameters (AST, ALT, T. Bilirubin, D. Bilirubin, PCR, CBC (WBCs, PLT, and HB), and T-cell activation marker (CD69). The flow- cytometer was used to measure CD69 %.
Results: The results of this study revealed significant increase in AST, ALT. D. Bilirubin, and CD69%. In hepatitis C patients comparing with controls. In addition, hepatitis C patients had statistically significant decrease in Albumin and PLT count less than controls. No statistically significant decrease was detected in HB and WBCs count in hepatitis C patients comparing with healthy control. and no statistically significant increase in T. Bilirubin in hepatitis C group more than control was detected.
Conclusion: The present study could suggest that CD69 cells are important determinants of immune status and prognosis in hepatitis C patients.
Keywords
hepatitis C; T-lymphocytes; T-activator cells; CD69
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