The effects of weight loss intervention program on serum leptin level, histological and molecular alterations of adipose tissue in rat model with obesity. | ||
Biochemistry Letters | ||
Article 8, Volume 16, Issue 1, 2020, Pages 101-108 PDF (319.24 K) | ||
Document Type: Original Article | ||
DOI: 10.21608/blj.2020.146598 | ||
Authors | ||
Nearmeen M. Rashad1; Sally E. Sayed2; Mohamed H. Sherif3; Mahmoud Z. Sitohy4 | ||
1Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||
2Biochemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt | ||
3Organic Chemistry Department, Faculty of Science Zagazig University, Zagazig, Egypt. | ||
4Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig Egypt. | ||
Abstract | ||
Background: Obesity is a resilient and complex chronic disease. Leptin is an adipocyte-derived hormone acts as a key regulator of feeding and energy expenditure. The aim of our study was to assess the level of serum leptin as well as leptin immuno-histochemistry expression in adipose tissue in obese and non-obese rats. Leptin was markedly detected in young preadipocytes during lipogenesis (before weight loss (regime) in contrast to adipocytes undergoing lipolysis (after weight loss (regime) in the later weak positive. | ||
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