Serum Interleukin 23 and Nitric Oxide in Vitiligo: New insights into the emerging association with VASI Score | ||
| Zagazig University Medical Journal | ||
| Article 39, Volume 29, Issue 2.1, March and April 2023, Pages 242-247 PDF (428.92 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2021.51028.2026 | ||
| Authors | ||
| Hagar Bessar* 1; Basma Ahmed2; Samar Mohamoud Sharaf3; Afaf Helmy Ghanem4 | ||
| 1Dermatololgy &Veneorology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||
| 2Dermatology and Venereology Department,faculty of medicine ,zagazig university,sharqia,egypt | ||
| 3Clinical Pathology Department Faculty of Medicine Zagazig University | ||
| 4Dermatology & Veneorology Department .Faculty of Medicine.Zagazig University | ||
| Abstract | ||
| Background: Vitiligo is a depigmentation disease of the skin caused by selective melanocyte degradation. In recent years, vitiligo has become known as an autoimmune disorder. Objectives: Our objective in this study was to determine serum levels of interleukin 23 (IL-23) and nitric oxide (NO) in vitiligo patients and their possible role in the pathogenesis of vitiligo, in an attempt to identify new treatment strategies. Methods: The autoimmune and autocytotoxic mechanisms of vitiligo development were investigated in a case-control study comparing 30 vitiligo patients to 30 healthy controls. Serum levels of IL-23 and NO were measured in vitiligo patients and healthy controls. The interactions between IL-23 and NO with different parameters in the vitiligo group were also examined. Results: Serum IL-23 and NO levels were higher in the vitiligo group compared with healthy controls (P | ||
| Keywords | ||
| Vitiligo; IL-23; Nitric oxide | ||
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