In Situ Hybridization and Light and Electron Microscopes of Cervical Squamous Cell Carcinoma Infected with Human Papillomavirus | ||
The Egyptian Journal of Hospital Medicine | ||
Article 12, Volume 61, Issue 1, October 2015, Pages 459-478 PDF (2.02 M) | ||
Document Type: Original Article | ||
DOI: 10.12816/0018751 | ||
Authors | ||
Monir A. El-Ganzuri1; Ali Khalifa2; Thanaa Helal3; Nanice Nabil Rizk1; Nora A. Al-Jalaud4 | ||
1Zoology department, Faculty of Science, Ain Shams University | ||
2Biochemistry department and Head of Oncology Diagnostic unit . Faculty of Medicine, Ain Shams University | ||
3Pathology department, Faculty of Medicine, Ain Shams University | ||
4Department of Biology,Faculty of Science,Dammam University,Saudi Arabia | ||
Abstract | ||
Aim of the work-In Egypt cervical carcinoma is ranked as a number 6 of all malignant tumors. There is growing evidence that the human papillomavirus (HPV) is associated with the development of cervical cancer. Patients and Methods-The present study hunted HPV in Egyptian biopsies of cervical cancer by using in situ hybridization (ISH) technique .Light microscopy and ultra-structural features accompanied by squamous cell carcinoma (SCC) of the cervix were monitored. Results-The ultra structural study revealed viral particles in some epithelial cell nuclei and cytoplasm in the moderately-differentiated squamous cell carcinoma. These were suggested to be Herpes Simplex Virus (HSV). Conclusion-The potential relation between HPV and HSV in the incidence of Cervical Squamous Cell Carcinoma is discussed. | ||
Keywords | ||
Hybridization; Cervical Squamous; carcinoma; Papillomavirus | ||
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