The Relation between Plasma Complement 4 d and Lupus Nephritis at Zagazig University Hospitals
Sakr, S., Abdelhady, A., Zidan, N., Kotb, L. (2022). The Relation between Plasma Complement 4 d and Lupus Nephritis at Zagazig University Hospitals. EKB Journal Management System, 28(4), 778-783. doi: 10.21608/zumj.2021.57612.2077
Sara M Sakr; Adlia M Abdelhady; Nahla Zidan; Lobna I Kotb. "The Relation between Plasma Complement 4 d and Lupus Nephritis at Zagazig University Hospitals". EKB Journal Management System, 28, 4, 2022, 778-783. doi: 10.21608/zumj.2021.57612.2077
Sakr, S., Abdelhady, A., Zidan, N., Kotb, L. (2022). 'The Relation between Plasma Complement 4 d and Lupus Nephritis at Zagazig University Hospitals', EKB Journal Management System, 28(4), pp. 778-783. doi: 10.21608/zumj.2021.57612.2077
Sakr, S., Abdelhady, A., Zidan, N., Kotb, L. The Relation between Plasma Complement 4 d and Lupus Nephritis at Zagazig University Hospitals. EKB Journal Management System, 2022; 28(4): 778-783. doi: 10.21608/zumj.2021.57612.2077

The Relation between Plasma Complement 4 d and Lupus Nephritis at Zagazig University Hospitals

Zagazig University Medical Journal
Article 21, Volume 28, Issue 4, July 2022, Pages 778-783    PDF (363.19 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.57612.2077
Authors
Sara M Sakr* 1; Adlia M Abdelhady2; Nahla Zidan3; Lobna I Kotb4
1Rheumatology department at zagazig university
2Rheumatology,Rehabilitation and Physical medicine department,Faculty of medicine, Zagazig University
3Clinical Pathology Department, Faculty of Medicine,Zagazig University, Zagazig, Egypt
4Rheumatology,Rehabilitation and physical medicine department,Zagazig University
Abstract
Lupus nephritis is a common and serious manifestation of systemic lupus erythematosus,its diagnosis is established by a combination of clinical ,laboratory, serological data and histology of the kidney. Plasma complement 4 d can be used to predict flare of lupus nephritis. Aim: The aim of our work was to assess the relation between plasma complement 4 d and lupus nephritis.. Methods: This study was carried out on 100 Lupus Nephritis patients fulfilled the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria and 100 apparently healthy age & sex matched controls. Plasma complement 4 d was detected by specific sandwich ELISA according to the instruction of the manufacturer (SunRed, Shanghi). Results: Our work showed that 24 hour urine protein,RBCs in urine, serum albumin, pus in urine were (significantly associated) with plasma C4d (unstandardized β=0.001, -0.213, 0.441, 0.041 and 0.024 respectively) (p < 0.05). Our results also revealed that there was statistically significant relations between plasma c4d and lupus nephritis in SLE patients (p < 0.05). Conclusion: The study evaluated the importance of Plasma complement 4d in lupus nephritis and confirmed that plasma complement 4d can be used as a very good marker of the flare of lupus nephritis.
Keywords
Systemic Lupus Erythematosis; Lupus nephritis; Complement 4 d
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