Ameliorative Effect of Vitamin E on Oxidative Stress Induced by Bisphenol A in Female Albino Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 3, Volume 65, Issue 1, October 2016, Pages 474-478 PDF (299.63 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0033755 | ||
| Authors | ||
| Eman Helal* 1; Neama M. Taha2; Ahmed M. mohamed3; Hoda M. Abu-Taleb4 | ||
| 1AlAzhar univ. | ||
| 2Physiology Department, College of Medicine | ||
| 3Clinical Pharmacology Department, Faculty Of Medicine, Zagazig University | ||
| 4Department of Environmental Research, Theodor Bilharz Research Institute, Cairo, Egypt. | ||
| Abstract | ||
| Objective: Oxidative stress is induced by bisphenol A (BPA) and affects many organs. Vitamin E is an effective antioxidant which prevents the activity of free radicals. This study was aimed to clarify the effect of vitamin E on the oxidative stress induced by chronic administration of BPA. Materials and methods: 30 female albino rats were divided into 3 groups (10/each); group1: control rats, group 2: rats treated with bisphenol A (20 mg/ kg.B.wt) for three months, and group 3: rats treated with bisphenol A (20 mg/kg.B.wt) for three months, then treated with BPA and vitamin E (0.57/100 g B.wt) for other 15 days. Results: BPA induced hormonal disrupt in liver and kidney dysfunctions and hyperlipidemia. Vitamin E ameliorated all these parameters. Conclusion: since we exposed to many harmful disruptions and oxidative stress compounds, we must take vitamin E as a protective agent. | ||
| Keywords | ||
| BPA; Vitamin E; sexual hormone; Liver; kidney; lipids | ||
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