Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode | ||
| Egyptian Journal of Chemistry | ||
| Article 43, Volume 64, Issue 6, June 2021, Pages 3121-3130 PDF (804.35 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.48845.2999 | ||
| Authors | ||
| Ahmed Abdelmogod Gahlan1; Sayed Mohamed Derayea2; Mahmoud Ahmed Omar3; Gamal Ahmed Saleh4; Ahmed Mogahed Haredy* 2 | ||
| 1Chemistry Department, Faculty of Science, Al-Azhar University, Assiut, Egypt | ||
| 2Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt | ||
| 3Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Minia | ||
| 4Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| A new simple, cheap, and rapid method to increase the sensitivity of pencil graphite electrode (PGE) to determine Linagliptin (LNG) was developed by modified PGE with copper microparticles (Cu-PGE). The disposable modified sensor electrode's preparation depended on the electrodeposition of Cu-microparticles on the PGE that can be applied for determined LNG by complexed it with Cu+2 ions and measure the LNG-Cu complex onto the Cu-PGE improved. The preparation of this modified electrode is easy, simple, and cheap, and has high sensitivity. The modified electrode detected the LNG in the LNG-Cu complex range from 47.25 - 283.53 ng mL-1 with detection and quantitative limits of 6.0 and 20.0 ng mL-1, respectively, with a correlation coefficient of 0.9995. The proposed method was applied with success to determined LNG in the dosage form, spiked urine, and spiked plasma samples; additionally, the obtained modified electrode was put in comparison with the reported electrodes. | ||
| Keywords | ||
| Square Wave Anodic Voltammetric; Linagliptin; Microparticles Copper Pencil Graphite Electrode; Dosage Form and Biological Fluids | ||
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