Anti-hyperlipidemic and Anti-hypercholesterolemic effect of aqueous extract of guava (Pisidum guajava Linn.) leaves on rats | ||
| Journal of Scientific Research in Science | ||
| Article 7, Volume 33, part1, September 2016, Pages 565-584 PDF (539.29 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jsrs.2016.15327 | ||
| Authors | ||
| Hanan M. F. Abd El-Wahab; Sahar M. Galal; Fatma H. Abd El-Razik; Dina H. Sayed* | ||
| Biochemistry and Nutrition Department, Women’s Collage for Art, Science and Education, Ain Shams University, Cairo, Egypt. | ||
| Abstract | ||
| The aim of the present study is to investigate the ameliorative effect of aqueous guava leaf extract (AGLE) with different doses (200, 350, 500 & 650 mg/kg b.wt.) taken p.o in rats fed high fat high cholesterol (HFC) diet for 8 weeks. The four doses of AGLE cause a significant decrease in food intake, final body weight, gain in body weight, serum TAG, VLDL-C, risk ratio as well as liver TAG and malondialdehyde level. Also doses of AGLE (350,500 and 650 mg/kg b.wt.) cause a significant decrease in relative liver weight, serum AST and LDL-C but a significant increase in HDL-C and leptin hormone. While doses (500 & 650 mg/kg b.wt.) cause a significant decrease in serum TC. The highest dose causes a significant decrease in serum ALT and adiponectin hormone. Total liver cholesterol was decreased significantly in groups given (200 & 350 mg/kg b.wt.) but no significant decrease in doses (500 & 650 mg/kg b.wt.). As well as ghrelin hormone does not show significant decrease in the four treated groups fed HFC diet and given AGLE compared to rats fed HFC diet only. | ||
| Keywords | ||
| Guava leaves; HFC diet; Rats; adiponectin; leptin; ghrelin | ||
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