Testicular Ameliorative Effect of L- Carnitine on Monosodium Glutamate-Induced Testicular Structure Alterations in Male Mice | ||
| Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry | ||
| Article 2, Volume 13, Issue 1, June 2021, Pages 13-30 PDF (1.22 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsd.2021.154503 | ||
| Authors | ||
| Abdelkarimو M. Abdellateif; Wesamو S. Twfeq | ||
| Zoology Department, Faculty of Science, Fayoum University | ||
| Abstract | ||
| This study was carried out to investigate the ameliorative effect of L-carnitine on monosodium glutamate (MSG)-induced testicular toxicity in male mice. Sixty adult male mice were randomized into 6 groups (n = 10). In addition, to the control male mice group (Gp1) that orally administered distilled water, Gp2 mice received 150 mg/kg/day L-carnitine for 35 days. Monosodium glutamate (MSG) was orally administered to male mice at doses of 0.3 and 0.6 mg/g body weight individually (Gp3 & Gp4) and in combination with 150 mg/kg body weight of L-carnitine for 35 days (Gp5 & Gp6). The morphometric parameters, histopathological findings and immunohistochemical studies for PCNA, Ki-67 and Claudin-1 of the testis tissue demonstrated that L-carnitineattenuated and ameliorated the alterations in testicular tissues caused by MSG exposure. Conclusions: The findings of the present study indicated that treatment of male mice with L-carnitine banned MSG-induced testicular toxicity by improving testicular structure status. | ||
| Keywords | ||
| Monosodium glutamate; toxicity; testis; male mice and L-carintine | ||
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