Role of Vitamin D in Childhood Epilepsy | ||
| SVU-International Journal of Medical Sciences | ||
| Article 41, Volume 5, Issue 2, July 2022, Pages 410-419 PDF (234.04 K) | ||
| Document Type: Reviews Articles. | ||
| DOI: 10.21608/svuijm.2021.65108.1103 | ||
| Authors | ||
| Ahmed El-Abd Ahmed1; Mohammed H. Hassan2; Asmaa G. Mostafa* 1; Ali Helmi Bakry1 | ||
| 1Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| 2Department of Medical Biochemistry and Molecular Biology,Faculty of Medicine, South Valley University, Qena, Egypt | ||
| Abstract | ||
| Background:Vitamin D is a fat-soluble vitamin and also considered a steroid hormone, that plays an important role in the proper functioning of many organs of the body.Adequate vitamin D status plays a very important role in terms of appropriate brain development and function .Regarding vitamin D,it's participation in the central nervous system's function is corroborated by the presence of the enzyme 25(OH)D3-1alpha-hydroxylase, which form of the active form of vitaminD, and the presence of receptors of vitamin D (VDR) in the brain tissue , mostly in the hypothalamus and substantia nigra. The aim of this review: is to evaluate the roleof vitamin D in childhood epilepsy and to study the vitamin D –antiepleptic drugs interactions among epileptic children. Conclusion: vitamin D insufficiency and deficiency are highly prevalent among children with epilepsy.A lot of antiepileptic drugs lower vitamin D level and lead to more seizures specially enzyme inducers' drugs. | ||
| Keywords | ||
| Vitamin D; Epilepsy; Antiepileptic drugs | ||
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