Anti-inflammatory and Anti-nociceptive Effects of piperine in Gamma-irradiated Rats | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Article 1, Volume 29, Issue 1, December 2016, Pages 1-16 PDF (656.33 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2016.1575 | ||
| Abstract | ||
| PIPERINE is an alkaloid that is found naturally in plants belonging to the piperaceae family and has been reported to possess anti-inflammatory properties. The present study was constructed to investigate the possible anti-inflammatory and analgesic effects of piperine on different inflammatory models induced in irradiated rats. Paw volume and nociceptive threshold were measured in carrageenan-induced paw oedema and hyperalgesia model. Leukocytes count, tumour necrosis factor-α (TNF-α), prostaglandin E2 (PGE2), thiobarbituric acid reactive substances (TBARs) and total nitrate/nitrite (NOx) were estimated in the exudate collected from six-day old air pouch model. Irradiated rats were exposed to 6Gy gamma (γ)-irradiation. Oral administration of piperine at a dose of 50mg/ kg resulted in a significant decrement in the paw volume and significant increment in the nociceptive threshold, in non-irradiated and irradiated rats. The inflammation induced in irradiated rats in the six-day old air pouch model increased all the estimated parameters in the exudate whereas; piperine decreased their elevation in non-irradiated and irradiated rats. Piperine possesses a potential anti-inflammatory and anti-nociceptive activity on inflammation induced in irradiated rats. | ||
| Keywords | ||
| Inflammation; gamma-irradiation; Piperine; Carrageenan; air pouch | ||
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